引用本文:
Ming Ming Yan, Ting You Li, Da Qing Zhao, Shuai Shao, Sheng Nan Bi. A new derivative of triterpene with anti-melanoma B16 activity from Conyza canadensis[J]. Chinese Chemical Letters,
2010, 21(7): 834-837.
doi:
10.1016/j.cclet.2010.02.022
Citation: Ming Ming Yan, Ting You Li, Da Qing Zhao, Shuai Shao, Sheng Nan Bi. A new derivative of triterpene with anti-melanoma B16 activity from Conyza canadensis[J]. Chinese Chemical Letters, 2010, 21(7): 834-837. doi: 10.1016/j.cclet.2010.02.022
Citation: Ming Ming Yan, Ting You Li, Da Qing Zhao, Shuai Shao, Sheng Nan Bi. A new derivative of triterpene with anti-melanoma B16 activity from Conyza canadensis[J]. Chinese Chemical Letters, 2010, 21(7): 834-837. doi: 10.1016/j.cclet.2010.02.022
A new derivative of triterpene with anti-melanoma B16 activity from Conyza canadensis
摘要:
A new derivative of triterpene named Erigeronol 1 was isolated from the EtOH extract of the aerial part of Conyza canadensis together with 15 known compounds for the first time from this plant.The structure of Erigeronol 1 was elucidated as 3-O-(hydroxyacetyl)-23,28-dihydroxy-β-amyrin by hydrolysis and spectroscopic analysis.Erigeronol 1 showed potent cytotoxic activity with IC50 value of 7.77±0.47 μg/mL against melanoma B16 determined by the 3-(4,5-dimethylthiazo-2-yl)-2,5-dipbenyltetrazolium bromide(MTT)method.
English
A new derivative of triterpene with anti-melanoma B16 activity from Conyza canadensis
Abstract:
A new derivative of triterpene named Erigeronol 1 was isolated from the EtOH extract of the aerial part of Conyza canadensis together with 15 known compounds for the first time from this plant.The structure of Erigeronol 1 was elucidated as 3-O-(hydroxyacetyl)-23,28-dihydroxy-β-amyrin by hydrolysis and spectroscopic analysis.Erigeronol 1 showed potent cytotoxic activity with IC50 value of 7.77±0.47 μg/mL against melanoma B16 determined by the 3-(4,5-dimethylthiazo-2-yl)-2,5-dipbenyltetrazolium bromide(MTT)method.
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Key words:
- Conyza canadensis
- / Derivative of triterpene
- / Anti-melanoma B16
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