引用本文:
Lian Peng Tong, Jing Nan Cui, Wei Min Ren, Xing Yong Wang, Xu Hong Qian. Asymmetric bioreduction of substituted acenaphthenequinones using plant enzymatic systems: A novel strategy for the preparation of (+)-and(-)-mono hydroxyacenaphthenones[J]. Chinese Chemical Letters,
2008, 19(10): 1179-1182.
doi:
10.1016/j.cclet.2008.06.037
Citation: Lian Peng Tong, Jing Nan Cui, Wei Min Ren, Xing Yong Wang, Xu Hong Qian. Asymmetric bioreduction of substituted acenaphthenequinones using plant enzymatic systems: A novel strategy for the preparation of (+)-and(-)-mono hydroxyacenaphthenones[J]. Chinese Chemical Letters, 2008, 19(10): 1179-1182. doi: 10.1016/j.cclet.2008.06.037
Citation: Lian Peng Tong, Jing Nan Cui, Wei Min Ren, Xing Yong Wang, Xu Hong Qian. Asymmetric bioreduction of substituted acenaphthenequinones using plant enzymatic systems: A novel strategy for the preparation of (+)-and(-)-mono hydroxyacenaphthenones[J]. Chinese Chemical Letters, 2008, 19(10): 1179-1182. doi: 10.1016/j.cclet.2008.06.037
Asymmetric bioreduction of substituted acenaphthenequinones using plant enzymatic systems: A novel strategy for the preparation of (+)-and(-)-mono hydroxyacenaphthenones
摘要:
Regio- and enantioselective reduction of substituted acenaphthenequinones were conducted under mild reaction conditions using plant enzymatic systems.A screening of 15 plants allowed the selection of two suitable plants fulfilling enantiocomplementarity.The (+)-and(-)-mono hydroxyacenaphthenones were achieved with high conversion and good enantiomeric purity using peach(Prunus persica(L.)Batseh.,conversion 98%,71% ee)and carrot(Daucus carota L.,conversion 95%,81% ee),respectively.
English
Asymmetric bioreduction of substituted acenaphthenequinones using plant enzymatic systems: A novel strategy for the preparation of (+)-and(-)-mono hydroxyacenaphthenones
Abstract:
Regio- and enantioselective reduction of substituted acenaphthenequinones were conducted under mild reaction conditions using plant enzymatic systems.A screening of 15 plants allowed the selection of two suitable plants fulfilling enantiocomplementarity.The (+)-and(-)-mono hydroxyacenaphthenones were achieved with high conversion and good enantiomeric purity using peach(Prunus persica(L.)Batseh.,conversion 98%,71% ee)and carrot(Daucus carota L.,conversion 95%,81% ee),respectively.
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Key words:
- Bioreduction
- / Plant enzymes
- / Acenaphthenequinone
- / Chiral hydroxyacenaphthenone
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