Glyoxylic acid as catalyst: A simple selective synthesis of 1,2-disubstituted benzimidazoles in aqueous media

Shivaji S. Pawar Deepak V. Dekhane Murlidhar S. Shingare Shivaji N. Thore

引用本文: Shivaji S. Pawar,  Deepak V. Dekhane,  Murlidhar S. Shingare,  Shivaji N. Thore. Glyoxylic acid as catalyst: A simple selective synthesis of 1,2-disubstituted benzimidazoles in aqueous media[J]. Chinese Chemical Letters, 2008, 19(9): 1055-1058. doi: 10.1016/j.cclet.2008.06.028 shu
Citation:  Shivaji S. Pawar,  Deepak V. Dekhane,  Murlidhar S. Shingare,  Shivaji N. Thore. Glyoxylic acid as catalyst: A simple selective synthesis of 1,2-disubstituted benzimidazoles in aqueous media[J]. Chinese Chemical Letters, 2008, 19(9): 1055-1058. doi: 10.1016/j.cclet.2008.06.028 shu

Glyoxylic acid as catalyst: A simple selective synthesis of 1,2-disubstituted benzimidazoles in aqueous media

  • 基金项目:

    The authors are thankful to Head, Department of Chemistry, Vinayakrao Patil Mahavidyala Vaijapur 423701 (M.S.), India, for partial support of this work.

摘要: Glyoxylic acid (5 mol%) performs as a novel highly water-soluble catalyst for the synthesis of 2-aryl-l-arylmethyl-lH-benzimidazoles from a wide range of substituted o-phenylenediamines and various substituted aldehydes in good to excellent isolated yields (85-95%) using water as solvent at ambient temperature. The remarkable advantages offered by this method are easily and inexpensive available catalyst, simple procedure, mild conditions, much faster (20-40 min) reactions and excellent yields of products.

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  • 收稿日期:  2008-03-21
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