Synthesis of protected (2S,4R)-2-amino-4-methyldecanoic acid, a proposed component of culicinins

Wei Zhang Tian Tian Sun Duo Mei Jun Fei Wang Ying Xia Li

引用本文: Wei Zhang,  Tian Tian Sun,  Duo Mei,  Jun Fei Wang,  Ying Xia Li. Synthesis of protected (2S,4R)-2-amino-4-methyldecanoic acid, a proposed component of culicinins[J]. Chinese Chemical Letters, 2008, 19(9): 1068-1070. doi: 10.1016/j.cclet.2008.06.027 shu
Citation:  Wei Zhang,  Tian Tian Sun,  Duo Mei,  Jun Fei Wang,  Ying Xia Li. Synthesis of protected (2S,4R)-2-amino-4-methyldecanoic acid, a proposed component of culicinins[J]. Chinese Chemical Letters, 2008, 19(9): 1068-1070. doi: 10.1016/j.cclet.2008.06.027 shu

Synthesis of protected (2S,4R)-2-amino-4-methyldecanoic acid, a proposed component of culicinins

  • 基金项目:

    This work was financially supported by the National Natural Science Foundation of China (No. 30572245), Hi- Tech Research and Development Program of China (863 program, No. 2006AA09Z409), and The Excellent Young Scientists Foundation of Shandong Province (No. 2006BS02013).

摘要: The protected 2S,4R-2-amino-4-methyldecanoic acid, a proposed component of culicinins has been synthesized over 10 steps and in total 28% yields using Wittig reaction and SchÖllkopf amino acid synthesis as key steps.

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  • 收稿日期:  2008-03-27
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