引用本文:
Die Cheng, Deng Ke Liu, Mo Liu, Ying Liu, Wei Ren Xu, Chang Xiao Liu. Synthesis, activity evaluation and 3D-QSAR study of some novel derivatives of 4, 5, 6, 7-tetrahydrothieno [3,2-c] pyridine[J]. Chinese Chemical Letters,
2008, 19(9): 1075-1079.
doi:
10.1016/j.cclet.2008.06.008
Citation: Die Cheng, Deng Ke Liu, Mo Liu, Ying Liu, Wei Ren Xu, Chang Xiao Liu. Synthesis, activity evaluation and 3D-QSAR study of some novel derivatives of 4, 5, 6, 7-tetrahydrothieno [3,2-c] pyridine[J]. Chinese Chemical Letters, 2008, 19(9): 1075-1079. doi: 10.1016/j.cclet.2008.06.008
Citation: Die Cheng, Deng Ke Liu, Mo Liu, Ying Liu, Wei Ren Xu, Chang Xiao Liu. Synthesis, activity evaluation and 3D-QSAR study of some novel derivatives of 4, 5, 6, 7-tetrahydrothieno [3,2-c] pyridine[J]. Chinese Chemical Letters, 2008, 19(9): 1075-1079. doi: 10.1016/j.cclet.2008.06.008
Synthesis, activity evaluation and 3D-QSAR study of some novel derivatives of 4, 5, 6, 7-tetrahydrothieno [3,2-c] pyridine
摘要:
A series of novel derivatives of 4, 5, 6, 7-tetrahydrothieno[3,2-c] pyridine were synthesized and strucmrally characterized by 1H NMR and MS. Their in vivo anti-platelet aggregation activities were evaluated. A 3D-QSAR was performed using the CoMFA and the CoMSIA. This model provided useful guidelines for novel anti-platelet thienopyridines design.
English
Synthesis, activity evaluation and 3D-QSAR study of some novel derivatives of 4, 5, 6, 7-tetrahydrothieno [3,2-c] pyridine
Abstract:
A series of novel derivatives of 4, 5, 6, 7-tetrahydrothieno[3,2-c] pyridine were synthesized and strucmrally characterized by 1H NMR and MS. Their in vivo anti-platelet aggregation activities were evaluated. A 3D-QSAR was performed using the CoMFA and the CoMSIA. This model provided useful guidelines for novel anti-platelet thienopyridines design.
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Key words:
- Thienopyfidines
- / Anti-platelet aggregation activities
- / P2Y12 receptors
- / 3D-QSAR
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