引用本文:
Hong Yu Shi, Rui Juan Song, Yu Fu, Na Yao, Yuan De Long, Tian Bao Huang. A chiral stationary phase with special hydrophobic framework for ligand-exchange chromatography[J]. Chinese Chemical Letters,
2007, 18(11): 1392-1394.
doi:
10.1016/j.cclet.2007.09.016
Citation: Hong Yu Shi, Rui Juan Song, Yu Fu, Na Yao, Yuan De Long, Tian Bao Huang. A chiral stationary phase with special hydrophobic framework for ligand-exchange chromatography[J]. Chinese Chemical Letters, 2007, 18(11): 1392-1394. doi: 10.1016/j.cclet.2007.09.016
Citation: Hong Yu Shi, Rui Juan Song, Yu Fu, Na Yao, Yuan De Long, Tian Bao Huang. A chiral stationary phase with special hydrophobic framework for ligand-exchange chromatography[J]. Chinese Chemical Letters, 2007, 18(11): 1392-1394. doi: 10.1016/j.cclet.2007.09.016
A chiral stationary phase with special hydrophobic framework for ligand-exchange chromatography
摘要:
A novel chiral stationary phase (CSP1) for ligand-exchange chromatography (CLEC) was prepared by firstly using dimethylchlorosilane as an endcapping reagent for decreasing residual silanol group on the surface of silica gel, and then introducing L-Pro as a chiral selector and hydrophobic octyl group to the silica gel surface simultaneously. The enantioseparations of 14 DL-amino acids on CSP1 were achieved with the enantioselectivity α ranging from 1.09 to 2.44 and the resolution Rs being between 0.8 and 6.3. The chromatographic performances of CSP1 with the bonded phase (CSP2) prepared using reference method were compared. The results showed that the column efficiency and resolution Rs of chiral stationary phase could be improved by using the above modifying method.
English
A chiral stationary phase with special hydrophobic framework for ligand-exchange chromatography
Abstract:
A novel chiral stationary phase (CSP1) for ligand-exchange chromatography (CLEC) was prepared by firstly using dimethylchlorosilane as an endcapping reagent for decreasing residual silanol group on the surface of silica gel, and then introducing L-Pro as a chiral selector and hydrophobic octyl group to the silica gel surface simultaneously. The enantioseparations of 14 DL-amino acids on CSP1 were achieved with the enantioselectivity α ranging from 1.09 to 2.44 and the resolution Rs being between 0.8 and 6.3. The chromatographic performances of CSP1 with the bonded phase (CSP2) prepared using reference method were compared. The results showed that the column efficiency and resolution Rs of chiral stationary phase could be improved by using the above modifying method.
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