Synthesis and anticancer activities of porphyrin induced anticancer drugs

Dong Hong Li Jun Lin Diao Ke Gui Yu Cheng He Zhou

引用本文: Dong Hong Li,  Jun Lin Diao,  Ke Gui Yu,  Cheng He Zhou. Synthesis and anticancer activities of porphyrin induced anticancer drugs[J]. Chinese Chemical Letters, 2007, 18(11): 1331-1334. doi: 10.1016/j.cclet.2007.09.012 shu
Citation:  Dong Hong Li,  Jun Lin Diao,  Ke Gui Yu,  Cheng He Zhou. Synthesis and anticancer activities of porphyrin induced anticancer drugs[J]. Chinese Chemical Letters, 2007, 18(11): 1331-1334. doi: 10.1016/j.cclet.2007.09.012 shu

Synthesis and anticancer activities of porphyrin induced anticancer drugs

  • 基金项目:

    The authors would like to express thanks to the Chongqing Science and Technology Council,for the financial support to this work.

摘要: In view of the property of porphyrin's accumulation selectively in tumor, the ftorafur was modified by binding a porphyrin block to improve its tumor targeting and reduce its side effects. These novel porphyrin derivatives and metal compounds were synthesized under mild conditions with satisfactory yield, and the constructions of all these new compounds were characterized by UV, IR, MS, 1H NMR spectra and elementary analysis. Their anticancer activities were evaluated by MTT assay; the results indicated that the anticancer activities of compounds 4a-c were twice as high as that of ftorafur.

English

  • 加载中
计量
  • PDF下载量:  2
  • 文章访问数:  1002
  • HTML全文浏览量:  38
文章相关
  • 收稿日期:  2007-06-07
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

/

返回文章