Synthesis of mangiferin derivates and study their potent PTP1B inhibitory activity

引用本文: Hong Gang Hu, Ming Juan Wang, Qing Jie Zhao, Shi Chong Yu, Chao Mei Liu, Qiu Ye Wu. Synthesis of mangiferin derivates and study their potent PTP1B inhibitory activity[J]. Chinese Chemical Letters, 2007, 18(11): 1323-1326. doi: 10.1016/j.cclet.2007.09.011 shu

Citation: Hong Gang Hu, Ming Juan Wang, Qing Jie Zhao, Shi Chong Yu, Chao Mei Liu, Qiu Ye Wu. Synthesis of mangiferin derivates and study their potent PTP1B inhibitory activity[J]. Chinese Chemical Letters, 2007, 18(11): 1323-1326. doi: 10.1016/j.cclet.2007.09.011 shu

Synthesis of mangiferin derivates and study their potent PTP1B inhibitory activity

a Department of Chemistry, College of Science, Wayne State University, Detroit, MI 48202, United States;
b Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
基金项目:
We thank The National Center for Drug Screening (Shanghai,PR China) for supplying data on PTP1B inhibitory activity of the compounds.This work was supported by a grant from Science&Technology Commission of Shanghai Municipality (No.054319909).

摘要: Protein tyrosine phosphatase 1B (PTP1B) has received considerable attention from the drug industry as a potential treatment fordiabetes mellitus. Mangiferin has been reported to possess significant antidiabetic activity. Based on the previous study, eight new mangiferin derivates were synthesized and evaluated for their PTP1B inhibitory activity. Some of them displayed good inhibitory activity on PTP1B.

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Synthesis of mangiferin derivates and study their potent PTP1B inhibitory activity

a Department of Chemistry, College of Science, Wayne State University, Detroit, MI 48202, United States;
b Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
Received Date: 05 June 2007
Fund Project:
We thank The National Center for Drug Screening (Shanghai,PR China) for supplying data on PTP1B inhibitory activity of the compounds.This work was supported by a grant from Science&Technology Commission of Shanghai Municipality (No.054319909).

Abstract: Protein tyrosine phosphatase 1B (PTP1B) has received considerable attention from the drug industry as a potential treatment fordiabetes mellitus. Mangiferin has been reported to possess significant antidiabetic activity. Based on the previous study, eight new mangiferin derivates were synthesized and evaluated for their PTP1B inhibitory activity. Some of them displayed good inhibitory activity on PTP1B.

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Synthesis of mangiferin derivates and study their potent PTP1B inhibitory activity

English

Synthesis of mangiferin derivates and study their potent PTP1B inhibitory activity

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

Synthesis of mangiferin derivates and study their potent PTP1B inhibitory activity

English

Synthesis of mangiferin derivates and study their potent PTP1B inhibitory activity

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

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