引用本文:
Hui Bin Zhang, Yu Shi Chi, Wen Long Huang, Shuai Jian Ni. Total synthesis of human urotension-Ⅱ by microwave-assisted solid phase method[J]. Chinese Chemical Letters,
2007, 18(8): 902-904.
doi:
10.1016/j.cclet.2007.06.002
Citation: Hui Bin Zhang, Yu Shi Chi, Wen Long Huang, Shuai Jian Ni. Total synthesis of human urotension-Ⅱ by microwave-assisted solid phase method[J]. Chinese Chemical Letters, 2007, 18(8): 902-904. doi: 10.1016/j.cclet.2007.06.002
Citation: Hui Bin Zhang, Yu Shi Chi, Wen Long Huang, Shuai Jian Ni. Total synthesis of human urotension-Ⅱ by microwave-assisted solid phase method[J]. Chinese Chemical Letters, 2007, 18(8): 902-904. doi: 10.1016/j.cclet.2007.06.002
Total synthesis of human urotension-Ⅱ by microwave-assisted solid phase method
摘要:
Human urotension-Ⅱ was synthesized efficiently on Wang resin under microwave irradiation using Fmoc/tBu orthogonal protection strategy. Disulphide bridge was formed on solid phase with the irradiation of microwave, then the whole peptide was cleaved from the resin. The purity of crude peptide cyclized under microwave irradiation was higher than that under room temperature.
English
Total synthesis of human urotension-Ⅱ by microwave-assisted solid phase method
Abstract:
Human urotension-Ⅱ was synthesized efficiently on Wang resin under microwave irradiation using Fmoc/tBu orthogonal protection strategy. Disulphide bridge was formed on solid phase with the irradiation of microwave, then the whole peptide was cleaved from the resin. The purity of crude peptide cyclized under microwave irradiation was higher than that under room temperature.
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Key words:
- Human urotension-Ⅱ
- / Microwave irradiation
- / Solid phase
- / Disulphide bridge
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