Study on the interaction between clarithromycin and bovine serum albumin in the imitated physiology solution

引用本文: She Ying Dong, Chun Xia Xue, Ting Lin Huang. Study on the interaction between clarithromycin and bovine serum albumin in the imitated physiology solution[J]. Chinese Chemical Letters, 2007, 18(6): 726-729. doi: 10.1016/j.cclet.2007.04.033 shu

Citation: She Ying Dong, Chun Xia Xue, Ting Lin Huang. Study on the interaction between clarithromycin and bovine serum albumin in the imitated physiology solution[J]. Chinese Chemical Letters, 2007, 18(6): 726-729. doi: 10.1016/j.cclet.2007.04.033 shu

Study on the interaction between clarithromycin and bovine serum albumin in the imitated physiology solution

a College of Sciences, Xi'an University of Architecture and Technology, Xi'an 710055, Shaanxi, China;
b School of Environment and Municipal Engineering, Xi'an University of Architecture and Technology, Xi'an 710055, Shaanxi, China
基金项目:
The authors gratefully acknowledge the support for this research by the Nature Science Foundation of Shaanxi Province in China (No. 2005B28).

摘要: The interaction between clarithromycin (CAM) and bovine serum albumin (BSA) was investigated using linear-sweep voltammetry in pH 7.4 phosphate buffer solution where CAM caused two irreversible reduction waves P₂ and P₃ on mercury electrode.The study showed that the formation constant and formation ratio for the interaction between CAM and BSA were 1.51×10¹² and 3:1 for P₂, 4.53×10⁵ and 1:1 for P₃, respectively.The ion strength enhanced the hydrophobic interaction between CAM and BSA.

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Study on the interaction between clarithromycin and bovine serum albumin in the imitated physiology solution

a College of Sciences, Xi'an University of Architecture and Technology, Xi'an 710055, Shaanxi, China;
b School of Environment and Municipal Engineering, Xi'an University of Architecture and Technology, Xi'an 710055, Shaanxi, China
Fund Project:
The authors gratefully acknowledge the support for this research by the Nature Science Foundation of Shaanxi Province in China (No. 2005B28).

Abstract: The interaction between clarithromycin (CAM) and bovine serum albumin (BSA) was investigated using linear-sweep voltammetry in pH 7.4 phosphate buffer solution where CAM caused two irreversible reduction waves P₂ and P₃ on mercury electrode.The study showed that the formation constant and formation ratio for the interaction between CAM and BSA were 1.51×10¹² and 3:1 for P₂, 4.53×10⁵ and 1:1 for P₃, respectively.The ion strength enhanced the hydrophobic interaction between CAM and BSA.

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Study on the interaction between clarithromycin and bovine serum albumin in the imitated physiology solution

English

Study on the interaction between clarithromycin and bovine serum albumin in the imitated physiology solution

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中国化学会秘书处

Study on the interaction between clarithromycin and bovine serum albumin in the imitated physiology solution

English

Study on the interaction between clarithromycin and bovine serum albumin in the imitated physiology solution

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

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CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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