引用本文:
Nian Guang Li, Qi Dong You, Xue Feng Huang, Jin Xin Wang, Qing Long Guo, Xiao Guang Chen, Yan Li, Hong Yan Li. Synthesis and antitumor activities of structure-related small molecular compounds of gambogic acid[J]. Chinese Chemical Letters,
2007, 18(6): 659-662.
doi:
10.1016/j.cclet.2007.04.010
Citation: Nian Guang Li, Qi Dong You, Xue Feng Huang, Jin Xin Wang, Qing Long Guo, Xiao Guang Chen, Yan Li, Hong Yan Li. Synthesis and antitumor activities of structure-related small molecular compounds of gambogic acid[J]. Chinese Chemical Letters, 2007, 18(6): 659-662. doi: 10.1016/j.cclet.2007.04.010
Citation: Nian Guang Li, Qi Dong You, Xue Feng Huang, Jin Xin Wang, Qing Long Guo, Xiao Guang Chen, Yan Li, Hong Yan Li. Synthesis and antitumor activities of structure-related small molecular compounds of gambogic acid[J]. Chinese Chemical Letters, 2007, 18(6): 659-662. doi: 10.1016/j.cclet.2007.04.010
Synthesis and antitumor activities of structure-related small molecular compounds of gambogic acid
摘要:
Through simplifying the complicated skeleton of the natural product gambogic acid, two series derivatives of chromone and xanthone were synthesized and examined for their antitumor activities against several cancer cells in vitro by MTT method.The results showed that appropriate introduction of prenyl group to the small molecular compounds could elevate their antitumor activities.The structure-activities relationship of synthesized compounds certified that the bridgecore in gambogic acid was very important for keeping its antitumor activities.
English
Synthesis and antitumor activities of structure-related small molecular compounds of gambogic acid
Abstract:
Through simplifying the complicated skeleton of the natural product gambogic acid, two series derivatives of chromone and xanthone were synthesized and examined for their antitumor activities against several cancer cells in vitro by MTT method.The results showed that appropriate introduction of prenyl group to the small molecular compounds could elevate their antitumor activities.The structure-activities relationship of synthesized compounds certified that the bridgecore in gambogic acid was very important for keeping its antitumor activities.
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Key words:
- Gambogic acid
- / Small molecular compounds
- / Antitumor activity
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