Comparation of Activity against A Aggregation between RR and LPFFD

Jing Liu Zhi Yuan

Citation:  Jing Liu, Zhi Yuan. Comparation of Activity against A Aggregation between RR and LPFFD[J]. Chinese Journal of Polymer Science, 2015, 33(7): 1009-1017. doi: 10.1007/s10118-015-1646-7 shu

Comparation of Activity against A Aggregation between RR and LPFFD

  • 基金项目:

    This work was financially supported by the National Natural Science Foundation of China (Nos. 20634030 and 51273094), State Key Fundamental RD Project (No. 2011CB606202), and PCSIRT (No. IRT1257).

摘要: Here, we introduce the design of the structure of RR (RYYAAFFARR), an inhibitor of A aggregation, using molecular docking, and compare the inhibitory ability between RR and LPFFD, which interacts with A mainly depending on hydrophobic interaction. Our results showed that RR which can target multiple regions of A with multiple weak interactions is better than those that only target a single region with the single driving force mainly.

English

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  • 发布日期:  2015-07-05
  • 收稿日期:  2014-10-30
  • 修回日期:  2015-01-07
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