引用本文:
Qing Xuan XU, Li LI, Hao YUE, Zhi Qiang LIU, Ming Quan GUO, Shu Ying LIU. Detection and Characterization of Non-covalent Complex between Lappaconitine and β-Cyclodextrin by Electrospray Ionization Tandem Mass Spectrometry[J]. Chinese Chemical Letters,
2006, 17(1): 65-68.
Citation: Qing Xuan XU, Li LI, Hao YUE, Zhi Qiang LIU, Ming Quan GUO, Shu Ying LIU. Detection and Characterization of Non-covalent Complex between Lappaconitine and β-Cyclodextrin by Electrospray Ionization Tandem Mass Spectrometry[J]. Chinese Chemical Letters, 2006, 17(1): 65-68.
Citation: Qing Xuan XU, Li LI, Hao YUE, Zhi Qiang LIU, Ming Quan GUO, Shu Ying LIU. Detection and Characterization of Non-covalent Complex between Lappaconitine and β-Cyclodextrin by Electrospray Ionization Tandem Mass Spectrometry[J]. Chinese Chemical Letters, 2006, 17(1): 65-68.
Detection and Characterization of Non-covalent Complex between Lappaconitine and β-Cyclodextrin by Electrospray Ionization Tandem Mass Spectrometry
摘要:
The non-covalent complexes between lappaconitine (LA) and β-cyclodextrin (β-CD) have been detected and characterized by electrospray ionization combined with ion trap tandem mass spectrometry (ESI-MSn). The experimental results showed that only 1:1 non-covalent complex can be formed in different starting molar ratios of LA to β-CD. Furthermore, the diagnostic fragmentation of the β-CD-LA complex, with a significant contribution of covalent fragmentation of LA leaving the N-acetyl anthranoyl (AN) moiety inserted to β-CD, provided the convincing evidence for the formation of non-covalent complex between LA and β-CD and the cite of LA molecule included to cavity of β-CD assigned to AN residue.
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关键词:
- Lappaconitine
- / β-cyclodextrin
- / non-covalent complex
- / ESI-MS
- / CID
English
Detection and Characterization of Non-covalent Complex between Lappaconitine and β-Cyclodextrin by Electrospray Ionization Tandem Mass Spectrometry
Abstract:
The non-covalent complexes between lappaconitine (LA) and β-cyclodextrin (β-CD) have been detected and characterized by electrospray ionization combined with ion trap tandem mass spectrometry (ESI-MSn). The experimental results showed that only 1:1 non-covalent complex can be formed in different starting molar ratios of LA to β-CD. Furthermore, the diagnostic fragmentation of the β-CD-LA complex, with a significant contribution of covalent fragmentation of LA leaving the N-acetyl anthranoyl (AN) moiety inserted to β-CD, provided the convincing evidence for the formation of non-covalent complex between LA and β-CD and the cite of LA molecule included to cavity of β-CD assigned to AN residue.
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Key words:
- Lappaconitine
- / β-cyclodextrin
- / non-covalent complex
- / ESI-MS
- / CID
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