引用本文:
Wen Hao WANG, Xiao Min ZOU, Xin ZHANG, Yi Qiu FU, Ping XU. Solid-phase Synthesis of PNA Monomer by Ugi Four-component Condensation Reaction[J]. Chinese Chemical Letters,
2005, 16(5): 585-588.
Citation: Wen Hao WANG, Xiao Min ZOU, Xin ZHANG, Yi Qiu FU, Ping XU. Solid-phase Synthesis of PNA Monomer by Ugi Four-component Condensation Reaction[J]. Chinese Chemical Letters, 2005, 16(5): 585-588.
Citation: Wen Hao WANG, Xiao Min ZOU, Xin ZHANG, Yi Qiu FU, Ping XU. Solid-phase Synthesis of PNA Monomer by Ugi Four-component Condensation Reaction[J]. Chinese Chemical Letters, 2005, 16(5): 585-588.
Solid-phase Synthesis of PNA Monomer by Ugi Four-component Condensation Reaction
摘要:
Peptide nucleic acids (PNA) oligomers were synthesized in most cases by peptide synthesis from N-protected monomers. In this work a new method of obtaining PNA monomer by Ugi four-component condensation reaction was tested by solid-phase synthesis. The Fmoc protected PNA monomer was build up with thymin-1-yl acetic acid, 3-methylbutyl aldehyde, Fmoc protected aminoethyl isocyanide and Gly-Wang resin.
English
Solid-phase Synthesis of PNA Monomer by Ugi Four-component Condensation Reaction
Abstract:
Peptide nucleic acids (PNA) oligomers were synthesized in most cases by peptide synthesis from N-protected monomers. In this work a new method of obtaining PNA monomer by Ugi four-component condensation reaction was tested by solid-phase synthesis. The Fmoc protected PNA monomer was build up with thymin-1-yl acetic acid, 3-methylbutyl aldehyde, Fmoc protected aminoethyl isocyanide and Gly-Wang resin.
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