An Improved Synthesis of Retinoic Acid from β-Ionone

Yao Dong HUANG Xiao Jie ZHANG Ze Xu WANG Fen Er CHEN

引用本文: Yao Dong HUANG,  Xiao Jie ZHANG,  Ze Xu WANG,  Fen Er CHEN. An Improved Synthesis of Retinoic Acid from β-Ionone[J]. Chinese Chemical Letters, 2003, 14(1): 29-31. shu
Citation:  Yao Dong HUANG,  Xiao Jie ZHANG,  Ze Xu WANG,  Fen Er CHEN. An Improved Synthesis of Retinoic Acid from β-Ionone[J]. Chinese Chemical Letters, 2003, 14(1): 29-31. shu

An Improved Synthesis of Retinoic Acid from β-Ionone

摘要: A convenient and large-scale preparation of rctinoic acid 1 from β-ionone in five steps with 38% overall yield is described. The key steps are the epoxidization of 2 with a new methylated agent and the condensation 4 with tetraethyl methylenediphophonate in one-pot procedure to prepare 6.

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  • 收稿日期:  2002-04-03
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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