Oxidation of the Norditerpenoid Alkaloids Isotalatizidine and 6-Epiforsticine

Zheng Bang LI Qiao Hong CHEN Feng Peng WANG Bo Gang LI

引用本文: Zheng Bang LI,  Qiao Hong CHEN,  Feng Peng WANG,  Bo Gang LI. Oxidation of the Norditerpenoid Alkaloids Isotalatizidine and 6-Epiforsticine[J]. Chinese Chemical Letters, 2000, 11(5): 421-424. shu
Citation:  Zheng Bang LI,  Qiao Hong CHEN,  Feng Peng WANG,  Bo Gang LI. Oxidation of the Norditerpenoid Alkaloids Isotalatizidine and 6-Epiforsticine[J]. Chinese Chemical Letters, 2000, 11(5): 421-424. shu

Oxidation of the Norditerpenoid Alkaloids Isotalatizidine and 6-Epiforsticine

  • 基金项目:

    We thank the National Natural Science Foundation of China (No.393707) and the Chengdu Diao Pharmaceutical Company for support of this work. We also thank Professor Xiao Tian LIANG for helpful discussion on the subject.

摘要: Oxidation of 1 with KMnO4 in acetone-H2O (1:1) for 1h gave nevadenine 2 (38%). But, 3 was formed in 98% yield when prolonging time and raising temperature (40℃). Reaction of 1 and 10 with Conforth reagent afforded the ketones 11 (55%), 12 (30%), and 13 (13%), 14 (20%), respectively. While oxidation of 7 and 15 with a variety of the oxidizing agents gave 17 only in low 20% of yield besides the minor 16. In addition, 1 was converted to 2 by the fungi Curvularia lunata.

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  • 收稿日期:  1999-11-26
  • 修回日期:  2000-03-07
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