引用本文:
房喻, 孙作民, 任铸, 向家兰, 薛志文, 李彤. 呋喃西林,呋喃西林类似物及其铜(Ⅱ)、锌(Ⅱ)、镍(Ⅱ)络合物的合成和抑菌作用[J]. 应用化学,
2016, 4(5): 69-71.
Citation: Fang Yu, Sun Zuomin, Ren Zhu, Xiang Jialan, Xue Zhiwen, Li Tong. SYNTHESIS AND BACTERIOSTASIS OF FURANCILIN COMPLEXES WITH COPPER(Ⅱ),ZINC(Ⅱ),AND NICKEL(Ⅱ)[J]. Chinese Journal of Applied Chemistry, 2016, 4(5): 69-71.
Citation: Fang Yu, Sun Zuomin, Ren Zhu, Xiang Jialan, Xue Zhiwen, Li Tong. SYNTHESIS AND BACTERIOSTASIS OF FURANCILIN COMPLEXES WITH COPPER(Ⅱ),ZINC(Ⅱ),AND NICKEL(Ⅱ)[J]. Chinese Journal of Applied Chemistry, 2016, 4(5): 69-71.
呋喃西林,呋喃西林类似物及其铜(Ⅱ)、锌(Ⅱ)、镍(Ⅱ)络合物的合成和抑菌作用
摘要:
近年来,文献上报导了许多缩氨基脲、缩氨基硫脲及其金属配合物的抗癌、抗微生物活性[1-2],发现金属配合物往往比配体表现出更高和更广泛的生物活性[3]。呋喃西林(O2N-C4H2O-CH=NNHCONH2)是一种曾用于临床的硝基呋喃类广谱抗菌药物。
English
SYNTHESIS AND BACTERIOSTASIS OF FURANCILIN COMPLEXES WITH COPPER(Ⅱ),ZINC(Ⅱ),AND NICKEL(Ⅱ)
Abstract:
Five complexes[Cu(FDSC)2]Cl2,[Cu(FDTSC)2]Cl2,[Cu(N-FDSC)]Cl2],[Zn(N-FDTSC)2] and[Ni(N-FDTSC)2] have been synthesized and characterized FDSCH=N-(2-furfural)-semicarbazone,FDTSCH=N-(2-furfural)-thiosemicarbazone, N-FDSCH=N-(5-nitro-2-furfural)-semicarbazone and N-FDTSCH=N-(5-nitro-2-furfural)-thiosemicar-bazone.It is found that N-FDSCH, N-FDTSCH,[Cu(N-FDSC)]Cl2] and[Zn(N-FDTSC)2] showed a significant bacteriostasis on Staphylococcus aureus, Bacillus subtilis and Escherichia Coli. The relationship between the bacteriostatic activity and the structure of the compounds is discussed in the paper.
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