引用本文:
杨子刚, 袁建军, 程时远. 聚(Nε-苄氧羰基赖氨酸)-聚乙二醇-聚(Nε-苄氧羰基赖氨酸)的合成及其表征[J]. 应用化学,
2004, 21(6): 637-640.
Citation: YANG Zi-Gang, YUAN Jian-Jun, CHENG Shi-Yuan. Synthesis and Characterization of Amphiphilic Triblock Copolymers Poly(Nε-CBZ-Lysine)-PEG-Poly(Nε-CBZ-Lysine)[J]. Chinese Journal of Applied Chemistry, 2004, 21(6): 637-640.
Citation: YANG Zi-Gang, YUAN Jian-Jun, CHENG Shi-Yuan. Synthesis and Characterization of Amphiphilic Triblock Copolymers Poly(Nε-CBZ-Lysine)-PEG-Poly(Nε-CBZ-Lysine)[J]. Chinese Journal of Applied Chemistry, 2004, 21(6): 637-640.
聚(Nε-苄氧羰基赖氨酸)-聚乙二醇-聚(Nε-苄氧羰基赖氨酸)的合成及其表征
摘要:
利用三光气合成了Nε-苄氧羰基赖氨酸酸酐(Lys(z)-NCA),并用双端氨基聚乙二醇做引发剂,在DMF中引发Lys(z)-NCA聚合,合成了聚(Nε-苄氧羰基赖氨酸)-聚乙二醇-聚(Nε-苄氧羰基赖氨酸)三嵌段共聚物。利用IR、1H NMR、DSC和GPC对其结构进行了表征,结果表明,这种方法能够合成分子量可控、分子量分布窄(Ip=1.06)的嵌段共聚物,产率95.4%。
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关键词:
- 聚乙二醇
- / 聚(Nε-苄氧羰基赖氨酸)三嵌段共聚物
English
Synthesis and Characterization of Amphiphilic Triblock Copolymers Poly(Nε-CBZ-Lysine)-PEG-Poly(Nε-CBZ-Lysine)
Abstract:
Lys(z)-NCA was synthesized from Nε-carbobenzoyloxy-L-Lysine and triphosgene in THF. Amphiphilic triblock copolymers poly(Nε-carbobenzyloxy-L-Lysine)(poly(Nε-CBZ-Lysine)-PEG-poly(Nε-CBZ-Lysine)) were synthesized in DMF in the condition that both amino-end PEG was used as initiator. The structures of the block copolymers were characterized by IR, 1H NMR, GPC and DSC. The results revealed that triblock copolymers with controlled Mn and narrow molecular weight distribution(Ip=1.06) were synthesized, the yield was 95.4%. These block copolymers are expected to have promising application in the field of biomaterials for the two components in block copolymers are both biocompatible.
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Key words:
- poly(ethylene glycol)
- / poly(Nε-carbobenzyloxy-L-Lysine)
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