引用本文:
李良, 李国明, 黎茂荣, 容品加. 聚乳酸载利福平微球的制备及其释药性能[J]. 应用化学,
2003, 20(1): 65-68.
Citation: LI Liang, LI Guo-Ming, LI Mao-Rong, RONG Pin-Jia. Preparation of Polylactic Acid Encapsulated RFP Microspheres and Drug-Releasing Performance[J]. Chinese Journal of Applied Chemistry, 2003, 20(1): 65-68.
Citation: LI Liang, LI Guo-Ming, LI Mao-Rong, RONG Pin-Jia. Preparation of Polylactic Acid Encapsulated RFP Microspheres and Drug-Releasing Performance[J]. Chinese Journal of Applied Chemistry, 2003, 20(1): 65-68.
聚乳酸载利福平微球的制备及其释药性能
English
Preparation of Polylactic Acid Encapsulated RFP Microspheres and Drug-Releasing Performance
Abstract:
Polylactic acid(PLA) microspheres(MS) were prepared by an oil-in-water solvent evaporation method to encapsulate rifampin(RFP). Effects of molecular weight of PLA, the drug content, microsphere size, pH value of medium on the drug-releasing performance of the PLA microspheres were investigated. The results showed that the greater the molecular weight of PLA, the less it degrades and the more slowly the drug release. Again, the greater the content of RFP and the greater the difference of drug concentration between in and out of the microsphere, the more quickly the drug releases. The smaller the microsphere size, the more quickly the drug releases. In the alkali medium, the PLA degrades more quickly, and RFP becomes more stable, resulting in the faster release of drug.
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Key words:
- polylactic acid
- / microsphere
- / refampin
- / drug release
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