引用本文:
李丽, 魏青, 高胜利, 张鹏, 史启祯. Co(AMP)2Cl2的合成及表征[J]. 应用化学,
2002, 19(9): 917-918.
Citation: LI Li, WEI Qing, GAO Sheng-Li, ZHANG Peng, SHI Qi-Zhen. Synthesis and Characterization of Co(AMP)2Cl2[J]. Chinese Journal of Applied Chemistry, 2002, 19(9): 917-918.
Citation: LI Li, WEI Qing, GAO Sheng-Li, ZHANG Peng, SHI Qi-Zhen. Synthesis and Characterization of Co(AMP)2Cl2[J]. Chinese Journal of Applied Chemistry, 2002, 19(9): 917-918.
Co(AMP)2Cl2的合成及表征
摘要:
嘧啶类化合物与金属离子形成的配合物作为药物添加剂,不仅可延长原药物的活性、持效期和半衰期,而且还能降低对哺乳动物的毒性。研究表明[1],Pt和Pd的嘧啶类配合物具有很好的抗癌效果,但对人体特别是肾脏等器官的毒性大;但若用人体必需的微量元素Cu、Zn、Co等代替Pt或Pd,则可能降低毒性。本文在文献[2]的基础上,选用氯化苄基三乙基铵为催化剂,并严格控制反应时间,提高了合成二甲氧基嘧啶胺(dimethoxypyrimidine,简称AMP)的产率,在无水乙醇中,制得了它与CoCl2·6H2O的固态配合物,用化学分析、元素分析、IR、XPS和1H NMR等方法对其进行了表征。
English
Synthesis and Characterization of Co(AMP)2Cl2
Abstract:
2-Amino-4,6-dimethoxypyrimidine(AMP) was synthesized using benzyltriethyl ammonium chloride(BTEA) as a catalyst in yield of 87.5%. A solid complex Co(AMP)2Cl2 was obtained by refluxing AMP with CoCl2 in ethanol. The composition of the complex was determined by chemical and elemental analyses. The structure of the complex and sp3 d2 of the hybridization type of Co2+ were estimated by IR, XPS and 1H NMR.
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Key words:
- cobalt chloride
- / amino dimethoxypyrimidine
- / synthesis
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