引用本文:
李曦, 刘义, 吴军, 屈松生. 微量热法研究硒代吗啉衍生物的抑菌作用[J]. 应用化学,
2002, 19(7): 645-648.
Citation: LI Xi, LIU Yi, WU Jun, QU Song-Sheng. Microcalorimetric Study on the Action of Selenomorpholine Derivatives on Growth Metabolism of Escherichia coli[J]. Chinese Journal of Applied Chemistry, 2002, 19(7): 645-648.
Citation: LI Xi, LIU Yi, WU Jun, QU Song-Sheng. Microcalorimetric Study on the Action of Selenomorpholine Derivatives on Growth Metabolism of Escherichia coli[J]. Chinese Journal of Applied Chemistry, 2002, 19(7): 645-648.
微量热法研究硒代吗啉衍生物的抑菌作用
English
Microcalorimetric Study on the Action of Selenomorpholine Derivatives on Growth Metabolism of Escherichia coli
Abstract:
The inhibitory or antibiotic actions of three kinds of the selenomorpholine derivatives on a strain of Escherichia coli have been studied by microcalorimetry. Differences in their abilities to inhibit the metabolism of this bacteria were observed. The extent and level of the inhibitory effect on the metabolism as judged by the rate constant, k, and the half-inhibitory concentration, IC50, varied with the kinds of drugs. The rate constant(k) of Escherichia coli in the presence of the drugs was found decreased with the increase in concentration of the drug. The experimental results revealed that the antibiotic activity of selenomorpholines was in order of: N-dodecyl-selenomorpholine-acetyl methyl ester bromide > N-dodecyl-selenomorpholine > 4-selenomorpholine-formylethyl ester.
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Key words:
- selenomorpholine derivative
- / Escherichia coli
- / metabolism
- / inhibition
- / microcalorimetry
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