引用本文:
陈敏东, 袁建超, 吕士杰, 杜小丽, 袁光谱, 杨世琰. 新的1-取代芳基-4-乙氧羰基-5-酰胺基-1,2,3-三唑的合成及抑菌性能[J]. 应用化学,
2001, 18(10): 772-776.
Citation: CHEN Min-Dong, YUAN Jian-Chao, LÜ Shi-Jie, DU Xiao-Li, YUAN Guang-Pu, YANG Shi-Yan. Synthesis and Antibacterial Activities of 1-Substituted Aryl-4-Ethoxycarbonyl-5-Acylamino-1,2,3-Triazoles[J]. Chinese Journal of Applied Chemistry, 2001, 18(10): 772-776.
Citation: CHEN Min-Dong, YUAN Jian-Chao, LÜ Shi-Jie, DU Xiao-Li, YUAN Guang-Pu, YANG Shi-Yan. Synthesis and Antibacterial Activities of 1-Substituted Aryl-4-Ethoxycarbonyl-5-Acylamino-1,2,3-Triazoles[J]. Chinese Journal of Applied Chemistry, 2001, 18(10): 772-776.
新的1-取代芳基-4-乙氧羰基-5-酰胺基-1,2,3-三唑的合成及抑菌性能
English
Synthesis and Antibacterial Activities of 1-Substituted Aryl-4-Ethoxycarbonyl-5-Acylamino-1,2,3-Triazoles
Abstract:
Twenty one new derivatives of 1-substituted aryl-4-ethoxy carbonyl-5-amino-1,2,3-triazole(compound 1) were obtained by reactions of 1-aryl-4-ethoxycarbonyl-5-amino-1,2,3-triazoles with benzoyl chloride, chloroacetyl chloride, propionyl chloride, acetyl chloride etc., in good yields(61%~91%). The relationships between yields and properties of acyl halides were discussed. The structures of all heterocyclic compounds were characterized by elemental analyses, IR, 1H NMR and MS. Their antibacterial activities against Klebsiella, Escherichia coli, Pseudomonas aeruginosa, Staphlococcus aureus and Proteus vulgaris were screened.
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Key words:
- triazole
- / synthesis
- / antibacterial activity
- / acyl halide
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