引用本文:
刘杰, 涂长春, 张茂林, 侯世宽, 王恩波. 钒取代杂多钨酸盐抗伪狂犬病病毒的活性[J]. 应用化学,
1998, 15(4): 41-44.
Citation: Liu Jie, Tu Changchun, Zhang Maolin, Hou Shikuan, Wang Enbo. Activity of Vanadium-substituted Heteropolytungstate to Antipseudorabies Virus[J]. Chinese Journal of Applied Chemistry, 1998, 15(4): 41-44.
Citation: Liu Jie, Tu Changchun, Zhang Maolin, Hou Shikuan, Wang Enbo. Activity of Vanadium-substituted Heteropolytungstate to Antipseudorabies Virus[J]. Chinese Journal of Applied Chemistry, 1998, 15(4): 41-44.
钒取代杂多钨酸盐抗伪狂犬病病毒的活性
English
Activity of Vanadium-substituted Heteropolytungstate to Antipseudorabies Virus
Abstract:
Some vanadium-substituted hetropolytungstates were synthesized. Their toxicity to the cells of RK and activity to antipseudorabies virus at nontoxic concentrations were tested by cell-culture methods. The results showed that some of the compounds had high anti-PRV activity at nontoxic concentration. Among them three had high antivirus and selective activity with median effective concentration 3.2~5.0 mg/L and cell median toxicity concentration 400~420 mg/L. At concentration of the compounds 12.5 mg/L the inhibition to PRV was more than 70%~80%, while virus TCID50 values descended four log. The relation between the structure and activity has been discussed briefly.
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