引用本文:
戚国荣, 杨云松, 杨士林, 章国林, 张庆地. 氯硝柳胺透皮控释给药的研究[J]. 应用化学,
1997, 14(4): 25-28.
Citation: Qi Guorong, Yang Yunsong, Yang Shilin, Zhang Guolin, Zhang Qingdi. Study on the Niclosamide Transdermal Therapeutic System[J]. Chinese Journal of Applied Chemistry, 1997, 14(4): 25-28.
Citation: Qi Guorong, Yang Yunsong, Yang Shilin, Zhang Guolin, Zhang Qingdi. Study on the Niclosamide Transdermal Therapeutic System[J]. Chinese Journal of Applied Chemistry, 1997, 14(4): 25-28.
氯硝柳胺透皮控释给药的研究
English
Study on the Niclosamide Transdermal Therapeutic System
Abstract:
The efficiency of penetration enhancers for niclosamide has been studied using double-cell skin permeation system. It was found that oleic acid was a good enhancer for niclosamide and was more efficient than azone. Azone showed a synergism with oleic acid or propylene glycol. It was also demonstrated that niclosamide could be used as a long-lasting liniment. The mechanism of the effect of azone and oleic acid has been investigated by IR and DSC techniques.
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Key words:
- niclosamide
- / transdermal therapeutic system
- / azone
- / oleic acid
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