引用本文:
苏桂发, 俞凌翀. 丙氨酸的双不对称合成[J]. 应用化学,
1993, 10(4): 75-76.
Citation: Su Guifa, Yu Lingchong. DOUBLE ASYMMETRIC SYNTHESIS OF ALANINE[J]. Chinese Journal of Applied Chemistry, 1993, 10(4): 75-76.
Citation: Su Guifa, Yu Lingchong. DOUBLE ASYMMETRIC SYNTHESIS OF ALANINE[J]. Chinese Journal of Applied Chemistry, 1993, 10(4): 75-76.
丙氨酸的双不对称合成
摘要:
氨基酸的不对称合成是近年来研究热点之一[1],双不对称合成新设想为高光学纯度物质的合成提供了一条有益的思路[2]。本文考察在手性相转移催化条件下,邻苯二甲酰亚胺钾与手性α-溴代丙酸龙脑酯的Gabriel反应制取光学活性丙氨酸,观察到显著的双不对称诱导效应。仪器为Perkin-Elmer 241MC型旋光仪、PE240-C型元素分析仪。邻苯二甲酰亚胺钾按文献[3]制备;α-溴代丙酸乙酯为上海试剂总厂产品,(一)-龙脑为贵州罗甸制药厂产品,[α]D25=-37.2,(C5,乙醇);α-溴代丙酸龙脑酯根据文献[4]制备并经过元素分析和光谱鉴定。
English
DOUBLE ASYMMETRIC SYNTHESIS OF ALANINE
Abstract:
Under phase transfer catalytic conditions, eight alanine optical isomers were synthesized with optical yields ranging from 0~52.1%. An obvious effect of the double asymmetric induction was observed.
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Key words:
- alanine
- / phase transfer catalysis
- / double asymmetric induction
- / synthesis
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