引用本文:
刘克良, 何炳林, 萧绍博. 4-(N-烷基)胺甲基苯丙氨酸的合成[J]. 应用化学,
1990, 7(4): 72-74.
Citation: Liu Keliang, He Binglin, Xiao Shaobo. SYNTHESIS OF 4-(N-SUBSTITUTED) AMINOMETHYL PHENYLALANINES[J]. Chinese Journal of Applied Chemistry, 1990, 7(4): 72-74.
Citation: Liu Keliang, He Binglin, Xiao Shaobo. SYNTHESIS OF 4-(N-SUBSTITUTED) AMINOMETHYL PHENYLALANINES[J]. Chinese Journal of Applied Chemistry, 1990, 7(4): 72-74.
4-(N-烷基)胺甲基苯丙氨酸的合成
摘要:
在生物活性肽研究中,通过在肽主链中引入特定结构的氨基酸,得到其活性类似物,可以使人们进一步认识肽结构与生物活性之间的关系,发展高活性、低副作用的肽类药物。
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关键词:
- 4-(N-烷基)-胺甲基苯丙氨酸
- / 非蛋白氨基酸
English
SYNTHESIS OF 4-(N-SUBSTITUTED) AMINOMETHYL PHENYLALANINES
Abstract:
The new 4-(-N-substituted) aminomethyl phenylalanines are presented. Dialkylamine rea-cted with N-acetyl-4-chloromethyl phenylalanine ethyl ester to give phenylalanine derivatives with basic side groups.After hydrolysis in hydrochloric acid and protection with Boc group the amino acids have been successfully used in solid phase peptide synthesis. This series amino acids combine basicity, aromaticity and hydrophilicity in the same molecule and have different N-dialkyl groups in length, they can be used in systematic research on structure-bioactivity relationships of peptides.
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