Citation: Wei Shuo FANG, Hong Yan LIU, Qi Cheng. Synthesis and Antitumor Activity of C-2/C-10 Modified Analogues of Docetaxel[J]. Chinese Chemical Letters, ;2005, 16(1): 38-40. shu

Synthesis and Antitumor Activity of C-2/C-10 Modified Analogues of Docetaxel

Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050

Received Date: 11 December 2003

Fund Project: Financial support from Funding to Outstanding Doctor Thesis Authors of Chinese Universities (Grant No. 199949) is gratefully acknowledged by W. S. Fang.

Four 10-propionyl docetaxel analogues (11a-d) with 2α-amido substituents were prepared, and their antitumor activity against three solid tumor cell lines and their drug-resistant counterparts were determined.
- Paclitaxel,
- docetaxel,
- 2α-amido analogues,
- 10-propionate.
1. [1]
  Wenfeng Zang , Yixin Sun , Jingyi Zhang , Yanzhong Hao , Qianhui Jin , Hongying Xiao , Zuo Zhang , Xianbao Shi , Jin Sun , Zhonggui He , Cong Luo , Bingjun Sun . Two-tailed modification module tuned steric-hindrance effect enabling high therapeutic efficacy of paclitaxel prodrug nanoassemblies. Chinese Chemical Letters, 2025, 36(5): 110230-. doi: 10.1016/j.cclet.2024.110230
2. [2]
  Chao Liu , Liming Gong , Yanhong Liu , Shuangqing Wang , Hao Wu , Liqing Chen , Mingji Jin , Zhonggao Gao , Wei Huang . Lipoic acid-locked reduction-responsive core-cross-linked micelles delivering paclitaxel for triple-negative breast cancer treatment. Chinese Chemical Letters, 2025, 36(8): 110570-. doi: 10.1016/j.cclet.2024.110570
3. [3]
  Lin Li , Bingjun Sun , Jin Sun , Lin Chen , Zhonggui He . Binary prodrug nanoassemblies combining chemotherapy and ferroptosis activation for efficient triple-negative breast cancer therapy. Chinese Chemical Letters, 2024, 35(10): 109538-. doi: 10.1016/j.cclet.2024.109538
4. [4]
  Yanye Fan , Jingjing Chen , Bichun Chen , Jinyu Bai , Bowen Yang , Feng Liang , Lijing Fang . Design, synthesis and biological evaluation of Leu₁₀-teixobactin analogues. Chinese Chemical Letters, 2025, 36(4): 110075-. doi: 10.1016/j.cclet.2024.110075
5. [5]
  Yixin Sun , Keke Yu , Xiuchun Guo , Lanlan Zong , Zhonggui He , Xiaohui Pu . Three-in-one reduction and acid-ignited micelles amplify antitumor efficacy via precise synergistic delivery of paclitaxel and naringenin. Chinese Chemical Letters, 2025, 36(6): 110393-. doi: 10.1016/j.cclet.2024.110393
6. [6]
  Yuan Xiong , Lan-Hui Qin , Bei Zhao , Lei-Zhi Xu , Yu-Fan Fan , Tian Tian , Hai-Rong Zeng , Ting Liu , Jian Huang , Jian-Ming Sun , Zhen-Hao Tian , Guang-Bo Ge . Structure-based design and development of halogenated-naphthalimides as potent hCYP1B1 inhibitors for overcoming paclitaxel resistance. Chinese Chemical Letters, 2025, 36(11): 110812-. doi: 10.1016/j.cclet.2024.110812
7. [7]
  Juan Guo , Mingyuan Fang , Qingsong Liu , Xiao Ren , Yongqiang Qiao , Mingju Chao , Erjun Liang , Qilong Gao . Zero thermal expansion in Cs₂W₃O₁₀. Chinese Chemical Letters, 2024, 35(7): 108957-. doi: 10.1016/j.cclet.2023.108957
8. [8]
  Yulong Shi , Fenbei Chen , Mengyuan Wu , Xin Zhang , Runze Meng , Kun Wang , Yan Wang , Yuheng Mei , Qionglu Duan , Yinghong Li , Rongmei Gao , Yuhuan Li , Hongbin Deng , Jiandong Jiang , Yanxiang Wang , Danqing Song . Chemical construction and anti-HCoV-OC43 evaluation of novel 10,12-disubstituted aloperine derivatives as dual cofactor inhibitors of TMPRSS2 and SR-B1. Chinese Chemical Letters, 2024, 35(5): 108792-. doi: 10.1016/j.cclet.2023.108792
9. [9]
  Xin Chen , Meng Zhao , Yan-Yuan Jia . Stable Eu(III)-based metal-organic framework for fluorescence sensing of benzaldehyde and its analogues. Chinese Journal of Structural Chemistry, 2025, 44(3): 100445-100445. doi: 10.1016/j.cjsc.2024.100445
10. [10]
  Kang Wei , Jiayu Li , Wen Zhang , Bing Yuan , Ming-De Li , Pingwu Du . A strained π-extended [10]cycloparaphenylene carbon nanoring. Chinese Chemical Letters, 2024, 35(5): 109055-. doi: 10.1016/j.cclet.2023.109055
11. [11]
  Haiming Wu , Gaya N. Andrew , Rajini Anumula , Zhixun Luo . Corrigendum to 'How ligand coordination and superatomic-states accommodate the structure and property of a metal cluster: Cu₄ (dppy)₄ Cl₂ vs. Cu₂₁ (dppy)₁₀ with altered photoluminescence' [Chin. Chem. Lett. 35 (2024) 108340]. Chinese Chemical Letters, 2024, 35(12): 109912-. doi: 10.1016/j.cclet.2024.109912
12. [12]
  Liangfeng Yang , Liang Zeng , Yanping Zhu , Qiuan Wang , Jinheng Li . Copper-catalyzed photoredox 1,4-amidocyanation of 1,3-enynes with N-amidopyridin-1-ium salts and TMSCN: Facile access to α-amido allenyl nitriles. Chinese Chemical Letters, 2024, 35(11): 109685-. doi: 10.1016/j.cclet.2024.109685
13. [13]
  . . University Chemistry, 2024, 39(10): 0-0.
14. [14]
  . . University Chemistry, 2025, 40(10): 0-0.
15. [15]
  . 第41卷第10期封面和目次. Acta Physico-Chimica Sinica, 2025, 41(10): -.
16. [16]
  Yu Xia , Yangming Jiang , Xin-Long Ni , Qiaochun Wang , Daoping Wang . A macrocycle-based "Russian doll": The smallest cucurbit[4]uril in cucurbit[10]uril. Chinese Chemical Letters, 2024, 35(12): 109782-. doi: 10.1016/j.cclet.2024.109782
17. [17]
  Ran Cen , Yan-Yan Tang , Li-Xia Chen , Zhu Tao , Xin Xiao . A novel supramolecular assembly based on nor-seco-cucurbit[10]uril for spermine sensing and artificial light-harvesting. Chinese Chemical Letters, 2025, 36(1): 109744-. doi: 10.1016/j.cclet.2024.109744
18. [18]
  Nanjiong Pang , Yunxiang He , Mingyao Wang , Xiaoling Wang , Junling Guo , Xuepin Liao , Bi Shi . Exploiting selective isotope exchange of amino–phenolic networks for boron-10 isotopologue separation. Chinese Chemical Letters, 2025, 36(10): 110914-. doi: 10.1016/j.cclet.2025.110914
19. [19]
  Jindong Hao , Yufen Lv , Shuyue Tian , Chao Ma , Wenxiu Cui , Huilan Yue , Wei Wei , Dong Yi . Additive-free synthesis of β-keto phosphorodithioates via geminal hydro-phosphorodithiolation of sulfoxonium ylides with P₄S₁₀ and alcohols. Chinese Chemical Letters, 2024, 35(9): 109513-. doi: 10.1016/j.cclet.2024.109513
20. [20]
  Shaojie Deng , Peihua Ma , Qinghong Bai , Xin Xiao . The transformation of nor-seco-cucurbit[10]uril to cucurbit[5]uril and cucurbit[8]uril controlled by its own concentration. Chinese Chemical Letters, 2025, 36(2): 109878-. doi: 10.1016/j.cclet.2024.109878

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