Citation: Song Qing WANG, Xiu Jie LIU, Zhi Ming YI, Kang ZHAO. Design and Synthesis of New Arylsulfonamide and Arylamide Derivatives for the Platelet Aggression Inhibitor[J]. Chinese Chemical Letters, ;2003, 14(6): 581-584. shu

Design and Synthesis of New Arylsulfonamide and Arylamide Derivatives for the Platelet Aggression Inhibitor

1.
The College of Pharmaceuticals and Biotechnology, Tianjin University, Tianjin 300072;
2.
The School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016

Received Date: 22 July 2002

Fund Project: The authors would like to thank Professor Naili Wang for conducting the bioassay studies. KZ acknowledges supports from the National Young Scholar Award of the NSFC (#30125043) and from the Chung Kong Scholars Program administered by the Ministry of Education, PRC and the Li Ka Shing Foundation, Hong Kong.

A series of arylsulfonamide and arylamide derivatives have been prepared from anisolein good yields. The structures of those compounds were confirmed by ¹H-NMR and MS analysis.Their activities against platelet aggregation were tested in vitro by using the Born test on rabbits.
- Arylsulfonamide,
- arylamide,
- synthesis,
- platelet aggregation,
- inhibitor
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