Citation: Jin CHEN, Jun TIAN, Feng E WU, Norio Kawabe, Masahiko Tokuda. First Total Synthesis of Cleroindicin B, (±) Cleroindicin C and E[J]. Chinese Chemical Letters, ;2001, 12(9): 771-774. shu

First Total Synthesis of Cleroindicin B, (±) Cleroindicin C and E

1.
Laboratory of Natural Materia Medica, Chengdu Institute of Biology, the Chinese Academy of Sciences, Chengdu 610041;
2.
Basic Research Laboratories, Toray Industries, Inc., Tebiro 1111, Kamakura, Kanagawa 248, Japan

Received Date: 22 February 2001

Fund Project: This work was financially supported by Di-Ao Science Fund, Chinese Academy of Sciences. We are grateful to Mr. F. Su and Mrs. B. R. Bai for recording the NMR spectra.

Cleroindicin B, C and E, three new natural products originally isolated from Clerodendrum indicum, have been synthesized (in racemic forms for Cleroindicin C and E) by a facile route, starting from 2-(p-methoxy-phenyl) ethanol 1. The (±) cleroindicin C (5) has been resovled by the enantioselective inclusion methodology.
- Cleroindicin B,
- cleroindicin C,
- cleroindicin E,
- enantioselective inclusion methodology
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