Citation: Liang ZHOU, Shu Jie HOU, Peng XU, De Quan YU, Ping Sheng LEI, Chuan Chun ZOU. Synthesis and Antitumor Activities of 26-O-tert-Butyldimethylsiliyl Protodisogenyl β-D-Glucopyranoside[J]. Chinese Chemical Letters, ;2006, 17(5): 571-574. shu

Synthesis and Antitumor Activities of 26-O-tert-Butyldimethylsiliyl Protodisogenyl β-D-Glucopyranoside

Key Laboratory of Bioactive Substance and Resources Utilization of Chinese Herbal Medicine(Peking Union Medical College), Ministry of Education Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100050

Received Date: 31 October 2005

Fund Project: Financial support of this research by the National Natural Science Foundation of China (No. 20372085) is gratefully acknowledged by the authors.

New saponin 26-O-tert-butyldimethylsiliyl protodiosgenyl β-D-glucopyranoside 1 was synthesized and its cytotoxicity activity in vitro was evaluated by MTT. It showed potent antitumor activity to human cancer cells. E ring and C₂₂-OH play important roles in the antitumor activity of 1. A method to selective removal of acetyl group in the presence of benzoyl group was reported.
- Saponin,
- glycosylation,
- cytotoxicity activity,
- structure-activity relationship
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