Citation: Zhao Ruirui, Bai Yunfeng, Chen Xiaoliang, Feng Feng, Shuang Shaomin. Research Progress of Aptamers in Cancer Diagnosis and Targeted Therapy[J]. Chemistry, ;2020, 83(11): 977-985. shu

Research Progress of Aptamers in Cancer Diagnosis and Targeted Therapy

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College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, 030006
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College of Chemical and Environmental Engineering, Shanxi Datong University, Datong, 037009

Corresponding author: Bai Yunfeng, baiyunfeng1130@126.com Feng Feng, feng-feng64@263.net Shuang Shaomin, smshuang@sxu.edu.cn
Received Date: 8 June 2020
Accepted Date: 17 July 2020

Figures(5)

Nucleic acid aptamers are oligonucleotide fragments obtained from nucleic acid molecule libraries using in vitro screening technology, namely exponentially enriched ligand system evolution technology (SELEX). They have high specificities and affinities to the targets. The biosensing research using the aptamer as the recognition unit and the in vivo and in vitro imaging research of the aptamer coupling imaging reagents have great application prospects in clinical diagnosis. In addition, aptamers targeting cancer cells or tissues have fewer side effects than traditional chemotherapeutics, and they also have great application prospects in the clinic. This article reviews the current research progress of aptamers in cancer diagnosis and targeted therapy, and analyzes the current problems and challenges.
- Aptamer,
- Biosensing,
- Imaging,
- Targeted therapy
1. [1]
  DeSantis C, Ma J, Bryan L, et al. CA Cancer J. Clin., 2014, 64(1): 52~62.
2. [2]
  Liu M, Li Z Y, Yang J J, et al. Cell Proliferation, 2016, 49(4): 409~420.
3. [3]
  Harbeck N, Penault-Llorca F, Cortes J, et al. Nat. Rev. Dis. Primers, 2019, 5: 1~31.
4. [4]
  Mayer G. Angew. Chem., 2009, 48(15): 2672~2689.
5. [5]
  Fish G, Haller J A, Ho A C, et al. Ophthalmology, 2003, 110(5): 979~986.
6. [6]
  Bayrac A T, Sefah K, Parekh P, et al. ACS Chem. Neurosci., 2011, 2(3): 175~181.
7. [7]
  Sun H G, Zhu X, Lu P Y, et al. Mol. Ther-Nucl. Acids, 2014, 3: 1~14.
8. [8]
  Chen C H B, Chernis G A, Hoang V Q, et al. PNAS, 2003, 100: 9226~9231.
9. [9]
  Shangguan D H, Li Y, Tang Z W, et al. PNAS, 2006, 103(32): 11838~11843.
10. [10]
  Sefah K, Phillips J A, Xiong X L, et al. Analyst, 2009, 134(9): 1765~1775.
11. [11]
  Li X, An Y, Jin J, et al. Anal. Chem., 2015, 87(9): 4941~4948.
12. [12]
  Bai Y F, Feng F, Zhao L, et al. Biosens. Bioelectron., 2013, 47: 265~270.
13. [13]
  Bai Y F, Feng F, Zhao L, et al. Analyst, 2014, 139 (8): 1843~1846.
14. [14]
  Bai Y F, Zhao R F, Feng F, et al. Anal. Lett., 2017, 50(4): 682~689.
15. [15]
  Liu H Y, Bai Y F, Feng F, et al. Anal. Methods, 2017, 9: 744~747.
16. [16]
  Liu H Y, Bai Y F, Feng F, et al. Sens. Actuat. B, 2018, 256: 413~419.
17. [17]
  Zhang Y, Bai Y F, Feng F, et al. Anal. Methods, 2016, 8: 6131~6134.
18. [18]
  Borissoff J I, Spronk H M H, Heeneman S, et al. Cardiovasc. Res., 2009, 82(3): 392~403.
19. [19]
  Liu Y, Wang H, Li S Y, et al. Sens. Actuat. B, 2018, 258: 402~407.
20. [20]
  Wu Y, Xiao F, Wu Z, et al. Anal. Chem., 2017, 89(5): 2852~2858.
21. [21]
  Zhu Y, Hu X C, Shi S, et al. Biosens. Bioelectron., 2016, 79: 205~212.
22. [22]
  Zhu R Q, Song J P, Shuang S M, et al. Talanta, 2019, 204: 294~303.
23. [23]
  Nagrath S, Sequist L V, Maheswaran S, et al. Nature, 2008, 450(7173): 1235~1239.
24. [24]
  Khoshfetrat S M, Mehrgardi M A. Bioelectrochemistry, 2017, 114: 24~32.
25. [25]
  Wang K, He M Q, Zhai F H, et al. Talanta, 2017, 166: 87~92.
26. [26]
  Wang K, Fan D Q, Liu Y Q, et al. Biosens. Bioelectron., 2015, 73: 1~6.
27. [27]
  Zhao Z, Xu L, Shi X, et al. Analyst, 2009, 134(9): 1808~1814.
28. [28]
  Song Y, Zhu Z, An Y, et al. Anal. Chem., 2013, 85(5): 4141~4149.
29. [29]
  Meng H M, Zhang X B, Lv Y F, et al. ACS Nano, 2014, 8(6): 6171~6181.
30. [30]
  Peng P, Du Y, Zheng J, et al. Angew. Chem. Int. Ed., 2019, 58(6): 1648~1653.
31. [31]
  Shi H, Tang Z, Kim Y, et al. Chem. Asian J., 2010, 5(10): 2209~2213.
32. [32]
  Hu H, Dai A, Sun J, et al. Nanoscale, 2013, 5: 10447~10454.
33. [33]
  Zhang Q, Yin T, Gao G, et al. ACS Appl. Mater. Interf., 2017, 9(21): 17777~17785.
34. [34]
  Zhao C H, Song X B, Jin W G, et al. Anal. Chim. Acta, 2019, 1056: 108~116.
35. [35]
  Dalia L C, Elizabeth J, You M, et al. WIREs Nanomed. Nanobiotechnol., 2011, 3(3): 328~340.
36. [36]
  Wang C H, Huang Y F, Yeh C K. Langmuir, 2011, 27(11): 6971~6976.
37. [37]
  Perkins A C, Missailidis S. Q. J. Nucl. Med. Mol. Im., 2007, 51(4): 292~296.
38. [38]
  Charlton J, Sennello J, Smith D. Chem. Biol., 1997, 4(11): 809~816.
39. [39]
  Li J, Zheng H, Bates P J, et al. Nucl. Med. Biol., 2014, 41(2): 179~185.
40. [40]
  Tan L, Neoh K G, Kang E T, et al. Macromol. Biosci., 2011, 11(10): 1331~1335.
41. [41]
  Zhu G Z, Zheng J, Song E Q, et al. PNAS, 2013, 110(20): 7998~8003.
42. [42]
  Zhang H M, Ma Y L, Xie Y, et al. Sci. Rep., 2015, 5: 1~8.
43. [43]
  Thelu H V P, Atchimnaidu S, Perumal D, et al. ACS Appl. Bio. Mater., 2019, 2(12): 5227~5234.
44. [44]
  Chang M, Yang C S, Huang D M, et al. ACS Nano, 2011, 5(8): 6156~6163.
45. [45]
  Liu Q, Wang D, Xu Z, et al. ChemBioChem, 2019, 20(9): 1139~1144.
46. [46]
  Tian Y, Huang Y, Chen T, et al. Chem. Commun., 2018, 54 (68): 9394~9397.
47. [47]
  Zhan Y, Ma W, Lin Y, et al. ACS Appl. Mater. Interf., 2019, 11(17): 15354~15365
48. [48]
  Lim K S, Lee D Y, Bull D A, et al. Adv. Funct. Mater., 2015, 25(34): 5445~5451.
49. [49]
  Ma W, Zhan Y, Lin Y, et al. Nano Lett., 2019, 19(7): 4505~4517.
50. [50]
  Rana S, Bajaj A, Mout R, et al. Adv. Drug. Del. Rev., 2012, 64(2): 200~216.
51. [51]
  Probst C E, Zrazhevskiy P, Bagalkot V, et al. Adv. Drug Del. Rev., 2013, 65(5): 703~718.
52. [52]
  Allen T M, Cullis P R. Adv. Drug Del. Rev., 2013, 65(1): 36~48.
53. [53]
  Wang Y X J, Xuan S, Port M, et al. Curr. Pharm. Des., 2013, 19(37): 6575~6593.
54. [54]
  Meng L, Zhang X, Lu Q, et al. Biomaterials, 2012, 33(6): 1689~1698.
55. [55]
  Ma X, Tao H, Yang K, et al. Nano Res., 2012, 5(3): 199~212.
56. [56]
  Guan Q, Zhou L L, Dong Y B, et al. Eur. J. Chem., 2020, 26: 5583~5591.
57. [57]
  Wu X, Wu M, Zhao J X. Nanomed. Nanotechnol., 2014, 10(2): 297~312.
58. [58]
  Zhu E T, Song X Y, Zhou W H, et al. J. Mater. Chem., 2009, 19(41): 7765~7770.
59. [59]
  Moosavian S A, Sahebkar A. Cancer Lett., 2019, 448: 144~154.
60. [60]
  Kang H, O'Donoghue M B, Liu H, et al. Chem. Commun., 2010, 46(2): 249~251.
61. [61]
  Choi W I, Kim J Y, Kang C, et al. ACS Nano, 2011, 5(3): 1995~2003.
62. [62]
  Kolovskaya O S, Zamay T N, Belyanina I V, et al. Mol. Ther. Nucl. Acids, 2017, 9: 12~21.
63. [63]
  Li Y, Wang X L, Gao L, et al. J. Mater. Sci., 2018, 50: 14134~14148.
64. [64]
  Chandrasekaran R, Lee A S W, Yap L W, et al. Nanoscale, 2016, 8(1): 187~196.
65. [65]
  Bala J, Bhaskar A, Varshney A, et al. RNA Biol., 2011, 8(1): 101~111.
66. [66]
  Han D, Zhu G, Wu C, et al. ACS Nano, 2013, 7(3): 2312~2319.
67. [67]
  Liu Y, Hou W J, Xia L, et al. Chem. Sci., 2018, 9: 7505~7509.
68. [68]
  Meng H M, Hu X X, Kong G Z, et al. Theranostics, 2018, 8(16): 4332~4344.
69. [69]
  Li H, Hu H T, Zhao Y J, et al. Anal. Chem., 2015, 87(7): 3736~3745.
70. [70]
  Cao Y, Dong H, Yang Z, et al. ACS Appl. Mater. Interf., 2017, 9(1): 159~166.
71. [71]
  Zhao C H, Song X B, Jin W G, et al. Anal. Chim. Acta, 2019, 1056: 108~116.
72. [72]
  Ouellet E, Foley J H, Conway E M, et al. Biotechnol. Bioeng., 2015, 112: 1506~1522.
73. [73]
  Levay A, Brenneman R, Hoinka J, et al. Nucl. Acids Res., 2015, 43: e82.
74. [74]
  Shao K, Ding W, Wang F, et al. PLoS One, 2011, 6: e24910.
75. [75]
  Krylova S M, Bruce C, Bagg E A, et al. Anal. Chem., 2015, 87: 1411~1419.
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