Citation: Zhao Ruirui, Bai Yunfeng, Chen Xiaoliang, Feng Feng, Shuang Shaomin. Research Progress of Aptamers in Cancer Diagnosis and Targeted Therapy[J]. Chemistry, ;2020, 83(11): 977-985. shu

Research Progress of Aptamers in Cancer Diagnosis and Targeted Therapy

1.
College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, 030006
2.
College of Chemical and Environmental Engineering, Shanxi Datong University, Datong, 037009

Corresponding author: Bai Yunfeng, baiyunfeng1130@126.com Feng Feng, feng-feng64@263.net Shuang Shaomin, smshuang@sxu.edu.cn
Received Date: 8 June 2020
Accepted Date: 17 July 2020

Figures(5)

Nucleic acid aptamers are oligonucleotide fragments obtained from nucleic acid molecule libraries using in vitro screening technology, namely exponentially enriched ligand system evolution technology (SELEX). They have high specificities and affinities to the targets. The biosensing research using the aptamer as the recognition unit and the in vivo and in vitro imaging research of the aptamer coupling imaging reagents have great application prospects in clinical diagnosis. In addition, aptamers targeting cancer cells or tissues have fewer side effects than traditional chemotherapeutics, and they also have great application prospects in the clinic. This article reviews the current research progress of aptamers in cancer diagnosis and targeted therapy, and analyzes the current problems and challenges.
- Aptamer,
- Biosensing,
- Imaging,
- Targeted therapy
1. [1]
  DeSantis C, Ma J, Bryan L, et al. CA Cancer J. Clin., 2014, 64(1): 52~62.
2. [2]
  Liu M, Li Z Y, Yang J J, et al. Cell Proliferation, 2016, 49(4): 409~420.
3. [3]
  Harbeck N, Penault-Llorca F, Cortes J, et al. Nat. Rev. Dis. Primers, 2019, 5: 1~31.
4. [4]
  Mayer G. Angew. Chem., 2009, 48(15): 2672~2689.
5. [5]
  Fish G, Haller J A, Ho A C, et al. Ophthalmology, 2003, 110(5): 979~986.
6. [6]
  Bayrac A T, Sefah K, Parekh P, et al. ACS Chem. Neurosci., 2011, 2(3): 175~181.
7. [7]
  Sun H G, Zhu X, Lu P Y, et al. Mol. Ther-Nucl. Acids, 2014, 3: 1~14.
8. [8]
  Chen C H B, Chernis G A, Hoang V Q, et al. PNAS, 2003, 100: 9226~9231.
9. [9]
  Shangguan D H, Li Y, Tang Z W, et al. PNAS, 2006, 103(32): 11838~11843.
10. [10]
  Sefah K, Phillips J A, Xiong X L, et al. Analyst, 2009, 134(9): 1765~1775.
11. [11]
  Li X, An Y, Jin J, et al. Anal. Chem., 2015, 87(9): 4941~4948.
12. [12]
  Bai Y F, Feng F, Zhao L, et al. Biosens. Bioelectron., 2013, 47: 265~270.
13. [13]
  Bai Y F, Feng F, Zhao L, et al. Analyst, 2014, 139 (8): 1843~1846.
14. [14]
  Bai Y F, Zhao R F, Feng F, et al. Anal. Lett., 2017, 50(4): 682~689.
15. [15]
  Liu H Y, Bai Y F, Feng F, et al. Anal. Methods, 2017, 9: 744~747.
16. [16]
  Liu H Y, Bai Y F, Feng F, et al. Sens. Actuat. B, 2018, 256: 413~419.
17. [17]
  Zhang Y, Bai Y F, Feng F, et al. Anal. Methods, 2016, 8: 6131~6134.
18. [18]
  Borissoff J I, Spronk H M H, Heeneman S, et al. Cardiovasc. Res., 2009, 82(3): 392~403.
19. [19]
  Liu Y, Wang H, Li S Y, et al. Sens. Actuat. B, 2018, 258: 402~407.
20. [20]
  Wu Y, Xiao F, Wu Z, et al. Anal. Chem., 2017, 89(5): 2852~2858.
21. [21]
  Zhu Y, Hu X C, Shi S, et al. Biosens. Bioelectron., 2016, 79: 205~212.
22. [22]
  Zhu R Q, Song J P, Shuang S M, et al. Talanta, 2019, 204: 294~303.
23. [23]
  Nagrath S, Sequist L V, Maheswaran S, et al. Nature, 2008, 450(7173): 1235~1239.
24. [24]
  Khoshfetrat S M, Mehrgardi M A. Bioelectrochemistry, 2017, 114: 24~32.
25. [25]
  Wang K, He M Q, Zhai F H, et al. Talanta, 2017, 166: 87~92.
26. [26]
  Wang K, Fan D Q, Liu Y Q, et al. Biosens. Bioelectron., 2015, 73: 1~6.
27. [27]
  Zhao Z, Xu L, Shi X, et al. Analyst, 2009, 134(9): 1808~1814.
28. [28]
  Song Y, Zhu Z, An Y, et al. Anal. Chem., 2013, 85(5): 4141~4149.
29. [29]
  Meng H M, Zhang X B, Lv Y F, et al. ACS Nano, 2014, 8(6): 6171~6181.
30. [30]
  Peng P, Du Y, Zheng J, et al. Angew. Chem. Int. Ed., 2019, 58(6): 1648~1653.
31. [31]
  Shi H, Tang Z, Kim Y, et al. Chem. Asian J., 2010, 5(10): 2209~2213.
32. [32]
  Hu H, Dai A, Sun J, et al. Nanoscale, 2013, 5: 10447~10454.
33. [33]
  Zhang Q, Yin T, Gao G, et al. ACS Appl. Mater. Interf., 2017, 9(21): 17777~17785.
34. [34]
  Zhao C H, Song X B, Jin W G, et al. Anal. Chim. Acta, 2019, 1056: 108~116.
35. [35]
  Dalia L C, Elizabeth J, You M, et al. WIREs Nanomed. Nanobiotechnol., 2011, 3(3): 328~340.
36. [36]
  Wang C H, Huang Y F, Yeh C K. Langmuir, 2011, 27(11): 6971~6976.
37. [37]
  Perkins A C, Missailidis S. Q. J. Nucl. Med. Mol. Im., 2007, 51(4): 292~296.
38. [38]
  Charlton J, Sennello J, Smith D. Chem. Biol., 1997, 4(11): 809~816.
39. [39]
  Li J, Zheng H, Bates P J, et al. Nucl. Med. Biol., 2014, 41(2): 179~185.
40. [40]
  Tan L, Neoh K G, Kang E T, et al. Macromol. Biosci., 2011, 11(10): 1331~1335.
41. [41]
  Zhu G Z, Zheng J, Song E Q, et al. PNAS, 2013, 110(20): 7998~8003.
42. [42]
  Zhang H M, Ma Y L, Xie Y, et al. Sci. Rep., 2015, 5: 1~8.
43. [43]
  Thelu H V P, Atchimnaidu S, Perumal D, et al. ACS Appl. Bio. Mater., 2019, 2(12): 5227~5234.
44. [44]
  Chang M, Yang C S, Huang D M, et al. ACS Nano, 2011, 5(8): 6156~6163.
45. [45]
  Liu Q, Wang D, Xu Z, et al. ChemBioChem, 2019, 20(9): 1139~1144.
46. [46]
  Tian Y, Huang Y, Chen T, et al. Chem. Commun., 2018, 54 (68): 9394~9397.
47. [47]
  Zhan Y, Ma W, Lin Y, et al. ACS Appl. Mater. Interf., 2019, 11(17): 15354~15365
48. [48]
  Lim K S, Lee D Y, Bull D A, et al. Adv. Funct. Mater., 2015, 25(34): 5445~5451.
49. [49]
  Ma W, Zhan Y, Lin Y, et al. Nano Lett., 2019, 19(7): 4505~4517.
50. [50]
  Rana S, Bajaj A, Mout R, et al. Adv. Drug. Del. Rev., 2012, 64(2): 200~216.
51. [51]
  Probst C E, Zrazhevskiy P, Bagalkot V, et al. Adv. Drug Del. Rev., 2013, 65(5): 703~718.
52. [52]
  Allen T M, Cullis P R. Adv. Drug Del. Rev., 2013, 65(1): 36~48.
53. [53]
  Wang Y X J, Xuan S, Port M, et al. Curr. Pharm. Des., 2013, 19(37): 6575~6593.
54. [54]
  Meng L, Zhang X, Lu Q, et al. Biomaterials, 2012, 33(6): 1689~1698.
55. [55]
  Ma X, Tao H, Yang K, et al. Nano Res., 2012, 5(3): 199~212.
56. [56]
  Guan Q, Zhou L L, Dong Y B, et al. Eur. J. Chem., 2020, 26: 5583~5591.
57. [57]
  Wu X, Wu M, Zhao J X. Nanomed. Nanotechnol., 2014, 10(2): 297~312.
58. [58]
  Zhu E T, Song X Y, Zhou W H, et al. J. Mater. Chem., 2009, 19(41): 7765~7770.
59. [59]
  Moosavian S A, Sahebkar A. Cancer Lett., 2019, 448: 144~154.
60. [60]
  Kang H, O'Donoghue M B, Liu H, et al. Chem. Commun., 2010, 46(2): 249~251.
61. [61]
  Choi W I, Kim J Y, Kang C, et al. ACS Nano, 2011, 5(3): 1995~2003.
62. [62]
  Kolovskaya O S, Zamay T N, Belyanina I V, et al. Mol. Ther. Nucl. Acids, 2017, 9: 12~21.
63. [63]
  Li Y, Wang X L, Gao L, et al. J. Mater. Sci., 2018, 50: 14134~14148.
64. [64]
  Chandrasekaran R, Lee A S W, Yap L W, et al. Nanoscale, 2016, 8(1): 187~196.
65. [65]
  Bala J, Bhaskar A, Varshney A, et al. RNA Biol., 2011, 8(1): 101~111.
66. [66]
  Han D, Zhu G, Wu C, et al. ACS Nano, 2013, 7(3): 2312~2319.
67. [67]
  Liu Y, Hou W J, Xia L, et al. Chem. Sci., 2018, 9: 7505~7509.
68. [68]
  Meng H M, Hu X X, Kong G Z, et al. Theranostics, 2018, 8(16): 4332~4344.
69. [69]
  Li H, Hu H T, Zhao Y J, et al. Anal. Chem., 2015, 87(7): 3736~3745.
70. [70]
  Cao Y, Dong H, Yang Z, et al. ACS Appl. Mater. Interf., 2017, 9(1): 159~166.
71. [71]
  Zhao C H, Song X B, Jin W G, et al. Anal. Chim. Acta, 2019, 1056: 108~116.
72. [72]
  Ouellet E, Foley J H, Conway E M, et al. Biotechnol. Bioeng., 2015, 112: 1506~1522.
73. [73]
  Levay A, Brenneman R, Hoinka J, et al. Nucl. Acids Res., 2015, 43: e82.
74. [74]
  Shao K, Ding W, Wang F, et al. PLoS One, 2011, 6: e24910.
75. [75]
  Krylova S M, Bruce C, Bagg E A, et al. Anal. Chem., 2015, 87: 1411~1419.
1. [1]
  Qilong Fang , Yiqi Li , Jiangyihui Sheng , Quan Yuan , Jie Tan . Magical Pesticide Residue Detection Test Strips: Aptamer-based Lateral Flow Test Strips for Organophosphorus Pesticide Detection. University Chemistry, 2024, 39(5): 80-89. doi: 10.3866/PKU.DXHX202310004
2. [2]
  Shuyu Liu , Xiaomin Sun , Bohan Song , Gaofeng Zeng , Bingbing Du , Chongshen Guo , Cong Wang , Lei Wang . Design and Fabrication of Phospholipid-Vesicle-based Artificial Cells towards Biomedical Applications. University Chemistry, 2024, 39(11): 182-188. doi: 10.12461/PKU.DXHX202404113
3. [3]
  Chunmei GUO , Weihan YIN , Jingyi SHI , Jianhang ZHAO , Ying CHEN , Quli FAN . Facile construction and peroxidase-like activity of single-atom platinum nanozyme. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1633-1639. doi: 10.11862/CJIC.20240162
4. [4]
  Siyi ZHONG , Xiaowen LIN , Jiaxin LIU , Ruyi WANG , Tao LIANG , Zhengfeng DENG , Ao ZHONG , Cuiping HAN . Targeting imaging and detection of ovarian cancer cells based on fluorescent magnetic carbon dots. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1483-1490. doi: 10.11862/CJIC.20240093
5. [5]
  Rui WU , Yankun ZHANG , Jiufu LU , Pengfei ZHANG , Yang WANG . Research process on radioactive ¹⁸F-labelled chemical agents as positron emission tomography imaging probes for tumour detection. Chinese Journal of Inorganic Chemistry, 2025, 41(9): 1702-1718. doi: 10.11862/CJIC.20240387
6. [6]
  Renyi Shao , Khurram Abbas , Vladimir Yu. Osipov , Haimei Zhu , Yuan Li , Usama , Hong Bi . Red-emitting carbon dots prepared from Epipremnum Aureum leaves extract for biological imaging. Acta Physico-Chimica Sinica, 2026, 42(2): 100134-0. doi: 10.1016/j.actphy.2025.100134
7. [7]
  Qiang HU , Zhiqi CHEN , Zhong CHEN , Xu WANG , Weina WU . Pyridinium-chalcone-based ClO^- fluorescent probe: Preparation and biological imaging applications. Chinese Journal of Inorganic Chemistry, 2025, 41(9): 1789-1795. doi: 10.11862/CJIC.20250086
8. [8]
  Jinlong YAN , Weina WU , Yuan WANG . A simple Schiff base probe for the fluorescent turn-on detection of hypochlorite and its biological imaging application. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1653-1660. doi: 10.11862/CJIC.20240154
9. [9]
  Lu XU , Chengyu ZHANG , Wenjuan JI , Haiying YANG , Yunlong FU . Zinc metal-organic framework with high-density free carboxyl oxygen functionalized pore walls for targeted electrochemical sensing of paracetamol. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 907-918. doi: 10.11862/CJIC.20230431
10. [10]
  Zhongxin YU , Wei SONG , Yang LIU , Yuxue DING , Fanhao MENG , Shuju WANG , Lixin YOU . Fluorescence sensing on chlortetracycline of a Zn-coordination polymer based on mixed ligands. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2415-2421. doi: 10.11862/CJIC.20240304
11. [11]
  Anbang Du , Yuanfan Wang , Zhihong Wei , Dongxu Zhang , Li Li , Weiqing Yang , Qianlu Sun , Lili Zhao , Weigao Xu , Yuxi Tian . Photothermal Microscopy of Graphene Flakes with Different Thicknesses. Acta Physico-Chimica Sinica, 2024, 40(5): 2304027-0. doi: 10.3866/PKU.WHXB202304027
12. [12]
  Qiaoqiao BAI , Anqi ZHOU , Xiaowei LI , Tang LIU , Song LIU . Construction of pressure-temperature dual-functional flexible sensors and applications in biomedicine. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2259-2274. doi: 10.11862/CJIC.20240128
13. [13]
  Bin SUN , Heyan JIANG . Glucose-modified bis-Schiff bases: Synthesis and bio-activities in Alzheimer′s disease therapy. Chinese Journal of Inorganic Chemistry, 2025, 41(7): 1338-1350. doi: 10.11862/CJIC.20240428
14. [14]
  Yang Meiqing , Lu Wang , Haozi Lu , Yaocheng Yang , Song Liu . Recent Advances of Functional Nanomaterials for Screen-Printed Photoelectrochemical Biosensors. Acta Physico-Chimica Sinica, 2025, 41(2): 100018-0. doi: 10.3866/PKU.WHXB202310046
15. [15]
  Min ZHAO , Tingxu LIU , Ye WANG , Xianghe CHEN , Buhui LIU , Manman XIE , Cuiping HAN . Antioxidant activity of ultra-small quercetin nanoprobes under imaging guidance. Chinese Journal of Inorganic Chemistry, 2026, 42(7): 1495-1504. doi: 10.11862/CJIC.20260016
16. [16]
  Liang TANG , Jingfei NI , Kang XIAO , Xiangmei LIU . Synthesis and X-ray imaging application of lanthanide-organic complex-based scintillators. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1892-1902. doi: 10.11862/CJIC.20240139
17. [17]
  Pengli GUAN , Renhu BAI , Xiuling SUN , Bin LIU . Trianiline-derived aggregation-induced emission luminogen probe for lipase detection and cell imaging. Chinese Journal of Inorganic Chemistry, 2025, 41(9): 1817-1826. doi: 10.11862/CJIC.20250058
18. [18]
  Bao Yu , Xinyi Zhao , Huan Zhang , Yiwen Li , Mingli Peng , Yongchen Gou , Guang Jia , Haiming Fan . 氢原子核的自述：磁共振成像的基本原理与医学应用. University Chemistry, 2026, 41(9): 202-209. doi: 10.12461/PKU.DXHX202507027
19. [19]
  Donghui PAN , Yuping XU , Xinyu WANG , Lizhen WANG , Junjie YAN , Dongjian SHI , Min YANG , Mingqing CHEN . Preparation and in vivo tracing of ⁶⁸Ga-labeled PM_2.5 mimetic particles for positron emission tomography imaging. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 669-676. doi: 10.11862/CJIC.20230468
20. [20]
  Yanxi LIU , Mengjia XU , Haonan CHEN , Quan LIU , Yuming ZHANG . A fluorescent-colorimetric probe for peroxynitrite-anion-imaging in living cells. Chinese Journal of Inorganic Chemistry, 2025, 41(6): 1112-1122. doi: 10.11862/CJIC.20240423

Get Citation

PDF

XML

Metrics

PDF Downloads(84)
Abstract views(5036)
HTML views(1310)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142