Citation: Qin Ting, Chen Pingping, Mo Li, Li Miao, Chen Zhiming. Syntheses of C₂ Axial Chiral Thioureas and Their Microwave-Assisted Catalytic Performance for Biginelli Reaction[J]. Chemistry, ;2020, 83(3): 258-264. shu

Syntheses of C₂ Axial Chiral Thioureas and Their Microwave-Assisted Catalytic Performance for Biginelli Reaction

Key Laboratory of Functional Materials Chemistry of Guizhou Province, School of Chemistry and Materials Science, Guizhou Normal University, Guiyang, 550001

Corresponding author: Chen Zhiming, czm000219@163.com
Received Date: 18 November 2019
Accepted Date: 26 December 2019

Figures(1)

Three kinds of structure-symmetric thiourea catalysts with multi-chiral center and multi-hydrogen bond with axial chiral amphiyl skeleton were synthesized and applied to the synthesis of 3, 4-dihydropyrimidine thioneone by Biginelli reaction. The results show that the synthesized axial chiral thioureas all show good catalytic activity, which can effectively improve the yield and enantioselectivity of the Biginelli reaction.
- 3, 4-Dihydropyrimidine,
- Thiourea,
- Asymmetric synthesis
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Syntheses of C2 Axial Chiral Thioureas and Their Microwave-Assisted Catalytic Performance for Biginelli Reaction

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通讯作者: 陈斌, bchen63@163.com

Syntheses of C₂ Axial Chiral Thioureas and Their Microwave-Assisted Catalytic Performance for Biginelli Reaction