Citation: Hong Liming, Tang Aiqing, Xie Xiaomin, Zhang Zhilan. Syntheses of 1, 4-Dihydropyridine Derivatives and Their Interaction with Bovine Serum Albumin[J]. Chemistry, ;2018, 81(6): 537-542. shu

Syntheses of 1, 4-Dihydropyridine Derivatives and Their Interaction with Bovine Serum Albumin

College of Chemistry and Environmental Science, Shangrao Normal University, Shangrao 334001

Corresponding author: Hong Liming, hlm2012love@163.com
Received Date: 29 December 2017
Accepted Date: 16 March 2018

Figures(8)

1, 4-Dihydropyridine derivatives were synthesized by one-pot methods using p-toluene sulfonic acid as catalyst, and characterized by IR, MS and ¹H NMR. The interaction of the compound 1a with bovine serum albumin (BSA) was studied using fluorescence and UV-Vis spectroscopy at different temperatures. Experimental results indicated that K_q, K_a, n, ΔS, ΔH were 2.43×10¹² L·mol^-1·s^-1, 4.15×10³L·mol^-1, 0.82, 65.12J·mol^-1·K^-1 and 1.24kJ·mol^-1, respectively, at 298K. The results showed that the compound 1a has a fluorescence quenching effect on BSA. Parameters of thermodynamic functions were calculated, and the interaction between BSA and 1a is determined as hydrophobic interaction.
- Bovine serum albumin,
- Fluorescence quenching,
- 1, 4-Dihydropyridine derivatives,
- Hydrophobic interaction
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沈阳化工大学材料科学与工程学院沈阳 110142