Citation: Hong Liming, Tang Aiqing, Xie Xiaomin, Zhang Zhilan. Syntheses of 1, 4-Dihydropyridine Derivatives and Their Interaction with Bovine Serum Albumin[J]. Chemistry, ;2018, 81(6): 537-542. shu

Syntheses of 1, 4-Dihydropyridine Derivatives and Their Interaction with Bovine Serum Albumin

College of Chemistry and Environmental Science, Shangrao Normal University, Shangrao 334001

Corresponding author: Hong Liming, hlm2012love@163.com
Received Date: 29 December 2017
Accepted Date: 16 March 2018

Figures(8)

1, 4-Dihydropyridine derivatives were synthesized by one-pot methods using p-toluene sulfonic acid as catalyst, and characterized by IR, MS and ¹H NMR. The interaction of the compound 1a with bovine serum albumin (BSA) was studied using fluorescence and UV-Vis spectroscopy at different temperatures. Experimental results indicated that K_q, K_a, n, ΔS, ΔH were 2.43×10¹² L·mol^-1·s^-1, 4.15×10³L·mol^-1, 0.82, 65.12J·mol^-1·K^-1 and 1.24kJ·mol^-1, respectively, at 298K. The results showed that the compound 1a has a fluorescence quenching effect on BSA. Parameters of thermodynamic functions were calculated, and the interaction between BSA and 1a is determined as hydrophobic interaction.
- Bovine serum albumin,
- Fluorescence quenching,
- 1, 4-Dihydropyridine derivatives,
- Hydrophobic interaction
1. [1]
  D M Stout, A I Meyers. Chem. Rev., 1982, 82(2): 23-243.
2. [2]
  O A Di Stil, S Visentin, C Clara et al. J. Med. Chem., 1998, 41(27): 5393-5401.
3. [3]
  R Shan, C Velazquez, E E Knaus. J. Med. Chem., 2004, 47(1): 254-261.
4. [4]
  S Lejon, I M Frick, L Bjorck et al. Biol. Chem., 2004, 279: 42924-42928.
5. [5]
  X Pan, P Qin, R Liu et al. J. Agr. Food Chem., 2011, 59: 6650-6656.
6. [6]
  V Dahiya, B Chaubey, A K Dhaharwal et al. Pestic. Biochem. Phys., 2017, 139: 92-100.
7. [7]
  G R Bardajee, Z Hooshyar. Mater. Sci. Eng. C, 2016, 62: 806-815.
8. [8]
  M S Ali, H A Al-Lohedan. J. Mol. Liq., 2017, 236: 232-240.
9. [9]
  A Hao, X Guo, Q Wu et al. J. Lumin., 2016, 170: 90-96.
10. [10]
  L Tang, S Li, H Bi et al. Food Chem., 2016, 196: 550-559.
11. [11]
  J Shi, D Pan, X Wang et al. J. Photochem. Photobiol, B, 2016, 162: 14-23.
12. [12]
  G Li, J Huang, T Chen et al. Carbohyd. Polym., 2017, 176: 75-82.
13. [13]
  C Hao, G Xu, Y Feng et al. Spectrochim. Acta A, 2017, 184: 191-197.
14. [14]
15. [15]
16. [16]
  M Karpuraranjith, S Thambidurai. Mater. Chem. Phys., 2017, 199: 370-378.
17. [17]
  A Hao, X Guo, Q Wu et al. J. Lumin., 2016, 170: 90-96.
18. [18]
19. [19]
  S Li, L Tang, H N Bi. Luminescence, 2016, 31(2): 442-452.
20. [20]
  H Yang, Q Liu, L Zhao et al. J. Sol. Chem., 2014, 43: 774-786.
21. [21]
  P D Ross, S Subramanian. Biochemistry, 1981, 20: 3096-3102.
1. [1]
  Yonghui ZHOU , Rujun HUANG , Dongchao YAO , Aiwei ZHANG , Yuhang SUN , Zhujun CHEN , Baisong ZHU , Youxuan ZHENG . Synthesis and photoelectric properties of fluorescence materials with electron donor-acceptor structures based on quinoxaline and pyridinopyrazine, carbazole, and diphenylamine derivatives. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 701-712. doi: 10.11862/CJIC.20230373
2. [2]
  Lulu DONG , Jie LIU , Hua YANG , Yupei FU , Hongli LIU , Xiaoli CHEN , Huali CUI , Lin LIU , Jijiang WANG . Synthesis, crystal structure, and fluorescence properties of Cd-based complex with pcu topology. Chinese Journal of Inorganic Chemistry, 2025, 41(4): 809-820. doi: 10.11862/CJIC.20240171
3. [3]
  Shuang Meng , Haixin Long , Zhou Zhou , Meizhu Rong . Inorganic Chemistry Curriculum Design and Implementation of Based on “Stepped-Task Driven + Multi-Dimensional Output” Model: A Case Study on Intermolecular Forces. University Chemistry, 2024, 39(3): 122-131. doi: 10.3866/PKU.DXHX202309008
4. [4]
  Xinyi Hong , Tailing Xue , Zhou Xu , Enrong Xie , Mingkai Wu , Qingqing Wang , Lina Wu . Non-Site-Specific Fluorescent Labeling of Proteins as a Chemical Biology Experiment. University Chemistry, 2024, 39(4): 351-360. doi: 10.3866/PKU.DXHX202310010
5. [5]
  Jianfeng Yan , Yating Xiao , Xin Zuo , Caixia Lin , Yaofeng Yuan . Comprehensive Chemistry Experimental Design of Ferrocenylphenyl Derivatives. University Chemistry, 2024, 39(4): 329-337. doi: 10.3866/PKU.DXHX202310005
6. [6]
  Zhaoyang WANG , Chun YANG , Yaoyao Song , Na HAN , Xiaomeng LIU , Qinglun WANG . Lanthanide(Ⅲ) complexes derived from 4′-(2-pyridyl)-2, 2′∶6′, 2″-terpyridine: Crystal structures, fluorescent and magnetic properties. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1442-1451. doi: 10.11862/CJIC.20240114
7. [7]
  Yikai Wang , Xiaolin Jiang , Haoming Song , Nan Wei , Yifan Wang , Xinjun Xu , Cuihong Li , Hao Lu , Yahui Liu , Zhishan Bo . 氰基修饰的苝二酰亚胺衍生物作为膜厚不敏感型阴极界面材料用于高效有机太阳能电池. Acta Physico-Chimica Sinica, 2025, 41(3): 2406007-. doi: 10.3866/PKU.WHXB202406007
8. [8]
  Yan ZHAO , Xiaokang JIANG , Zhonghui LI , Jiaxu WANG , Hengwei ZHOU , Hai GUO . Preparation and fluorescence properties of Eu³⁺-doped CaLaGaO₄ red-emitting phosphors. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1861-1868. doi: 10.11862/CJIC.20240242
9. [9]
  Liyang ZHANG , Dongdong YANG , Ning LI , Yuanyu YANG , Qi MA . Crystal structures, luminescent properties and Hirshfeld surface analyses of three cadmium(Ⅱ) complexes based on 2-(3-(pyridin-2-yl)-1H-pyrazol-1-yl)benzoate. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1943-1952. doi: 10.11862/CJIC.20240079
10. [10]
  Jingzhao Cheng , Shiyu Gao , Bei Cheng , Kai Yang , Wang Wang , Shaowen Cao . 4-氨基-1H-咪唑-5-甲腈修饰供体-受体型氮化碳光催化剂的构建及其高效光催化产氢研究. Acta Physico-Chimica Sinica, 2024, 40(11): 2406026-. doi: 10.3866/PKU.WHXB202406026
11. [11]
  Zhongyan Cao , Shengnan Jin , Yuxia Wang , Yiyi Chen , Xianqiang Kong , Yuanqing Xu . Advances in Highly Selective Reactions Involving Phenol Derivatives as Aryl Radical Precursors. University Chemistry, 2025, 40(4): 245-252. doi: 10.12461/PKU.DXHX202405186
12. [12]
  Xiao SANG , Qi LIU , Jianping LANG . Synthesis, structure, and fluorescence properties of Zn(Ⅱ) coordination polymers containing tetra-alkenylpyridine ligands. Chinese Journal of Inorganic Chemistry, 2024, 40(11): 2124-2132. doi: 10.11862/CJIC.20240158
13. [13]
  Gaofeng WANG , Shuwen SUN , Yanfei ZHAO , Lixin MENG , Bohui WEI . Structural diversity and luminescence properties of three zinc coordination polymers based on bis(4-(1H-imidazol-1-yl)phenyl)methanone. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 849-856. doi: 10.11862/CJIC.20230479
14. [14]
  Yi DING , Peiyu LIAO , Jianhua JIA , Mingliang TONG . Structure and photoluminescence modulation of silver(Ⅰ)-tetra(pyridin-4-yl)ethene metal-organic frameworks by substituted benzoates. Chinese Journal of Inorganic Chemistry, 2025, 41(1): 141-148. doi: 10.11862/CJIC.20240393
15. [15]
  Xin MA , Ya SUN , Na SUN , Qian KANG , Jiajia ZHANG , Ruitao ZHU , Xiaoli GAO . A Tb₂ complex based on polydentate Schiff base: Crystal structure, fluorescence properties, and biological activity. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1347-1356. doi: 10.11862/CJIC.20230357
16. [16]
  Jinlong YAN , Weina WU , Yuan WANG . A simple Schiff base probe for the fluorescent turn-on detection of hypochlorite and its biological imaging application. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1653-1660. doi: 10.11862/CJIC.20240154
17. [17]
  Xuewei BA , Cheng CHENG , Huaikang ZHANG , Deqing ZHANG , Shuhua LI . Preparation and luminescent performance of Sr_1-xZrSi₂O₇∶xDy³⁺ phosphor with high thermal stability. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 357-364. doi: 10.11862/CJIC.20240096
18. [18]
  Tianlong Zhang , Rongling Zhang , Hongsheng Tang , Yan Li , Hua Li . Online Monitoring and Mechanistic Analysis of 3,5-diamino-1,2,4-triazole (DAT) Synthesis via Raman Spectroscopy: A Recommendation for a Comprehensive Instrumental Analysis Experiment. University Chemistry, 2024, 39(6): 303-311. doi: 10.3866/PKU.DXHX202312006
19. [19]
  Zhuoming Liang , Ming Chen , Zhiwen Zheng , Kai Chen . Multidimensional Studies on Ketone-Enol Tautomerism of 1,3-Diketones By ¹H NMR. University Chemistry, 2024, 39(7): 361-367. doi: 10.3866/PKU.DXHX202311029
20. [20]
  Hui Wang , Abdelkader Labidi , Menghan Ren , Feroz Shaik , Chuanyi Wang . 微观结构调控的g-C₃N₄在光催化NO转化中的最新进展：吸附/活化位点的关键作用. Acta Physico-Chimica Sinica, 2025, 41(5): 100039-. doi: 10.1016/j.actphy.2024.100039

Get Citation

PDF

XML

Metrics

PDF Downloads(4)
Abstract views(199)
HTML views(16)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142