Citation: Yu Fen ZHAO, Jian Jun HU, Yong JU. Interaction between N-Phospho-Amino Acids and Nucleoside in Aqueous Medium[J]. Chinese Chemical Letters, ;2000, 11(5): 407-408. shu

Interaction between N-Phospho-Amino Acids and Nucleoside in Aqueous Medium

State Laboratory of Bioorganic Phosphorus Chemistry, Department of Chemislry, School of Life Science and Engineering, Tsinghua University, Beijing 100084

Received Date: 6 December 1999

Nucleosides were phosphorylated with different N-(O, O-diisopropyl) phosphoryl amino acids to give nucleoside mono phosphates in aqueous solution. 2', 3', and 5'-isomers had been confirmed by comparison with authentic samples on the basis of HPLC analysis. The conversion percentage of nucleoside indicated that N-(O, O-diisopropyl) phosphoryl aspartic acid reacted with adenosine and guanosine at a much higher rate than other kinds of N-phosphoryl amino acids, while phosphorylation of cytidine and uridine was relatively easy by using N-(O, O-diisopropyl) phosphoryl threonine. The result could give some clue to the prebiotic code origin of nucleic acid and protein.
- N-Phospho-amino acids,
- nucleoside mono phosphate,
- phosphorylation,
- uridylyl uridine (UpU),
- origin,
- chemical evolution
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