Citation: Shang Zhong LIU, Qing Xiao LI. Photoaffinity Probe Candidates for Gamma-aminobutyric Acid (GABA_A)-Gated Chloride Channel[J]. Chinese Chemical Letters, ;2004, 15(7): 771-773. shu

Photoaffinity Probe Candidates for Gamma-aminobutyric Acid (GABA_A)-Gated Chloride Channel

Shang Zhong LIU ^1, ,
Qing Xiao LI ²

1.
Department of Applied Chemistry, China Agricultural University, Beijing 100094;
2.
Department of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA

Received Date: 20 July 2003

Fund Project: This work was supported by a grant from Hawaii Heptachlor Education and Research Foundation, and USDA-ARS award number 58-5320-8-147.

New photoaffinity ligand candidates were synthesized based on 5-t-butyl-2-(4-(substituted-ethynyl)phenyl)-1, 3-dithiane for the noncompetitive blocker site on the gamma-aminobutyric acid-gated chloride channel. Their half-maximal inhibition concentrations ranged from 4 to 32 nmol/L as measured by 4'-ethynyl-4-n-[2,3-³H₂]-propylbicycloorthobenzoate (³H EBOB) assay.
- Photoaffinity labeling,
- GABA_A receptor,
- 1,3-dithianes
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