Citation: Qiu Yun CHEN, Qing Shan LIU, Christopher J. SCHOFIELD. Synthesis and Bioassay of 4-Substituted 2-Oxoglutaric Acids[J]. Chinese Chemical Letters, ;2006, 17(2): 156-158. shu

Synthesis and Bioassay of 4-Substituted 2-Oxoglutaric Acids

1.
Department of Chemistry, Huangshan University, Tunxi 245021;
2.
Department of Chemistry, University of Oxford, South Park Road, Oxford, OX1 3TA, UK

Received Date: 26 May 2005

Fund Project: We are grateful to the Natural Science Foundation of Anhui Province for the support.

Three 2-oxoglutaric acid analogues were synthesized. Their interaction with factorinhibiting hypoxia-inducible factor (FIH) was studied using LC-MS method. The results show that hydrophobic substitutes of 2-oxoglutaric acids have great influence on their inhibitor activity.
- 2-Oxoglutatic acid analogues,
- inhibitor
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