Citation: Bi Zhong LI, Yuan Fang LIU, Yong Hui WU, Hua YE. A NEW BIFUNCTIONAL CHELATING AGENT α,ε-N,N'-BIS(L-CYSTEINYL)-L-LYSINE FOR RADIOLABELLING OF MONOCLONAL ANTIBODIES WITH TECHNETIUM-99M[J]. Chinese Chemical Letters, ;1991, 2(4): 285-288. shu

A NEW BIFUNCTIONAL CHELATING AGENT α,ε-N,N'-BIS(L-CYSTEINYL)-L-LYSINE FOR RADIOLABELLING OF MONOCLONAL ANTIBODIES WITH TECHNETIUM-99M

1.
Department of Technical PhysicsYun;
2.
Department of Chemistry, Peking University, Beijing 100871

Received Date: 9 January 1991

Fund Project: We thank the National Natural Science Foundation of China for financial support.

α,ε-N,N'-bis(L-cysteinyl)-L-lysine was synthesized and characterized for the first time.It was then employed as a bifunctional chelating agent to chelate technetium-99m and subsequently conjugated to fragment F(ab')₂ of anti-gastric tumor monoclonal antibody 3G9.The radiolabelled antibody was satisfactorily stable and immunoreactive.
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