Citation: Hu Daihua, Chen Wang. Advances in Syntheses and Biological Activities of Vitamin D₂ Analogues[J]. Chemistry, ;2017, 80(8): 715-724. shu

Advances in Syntheses and Biological Activities of Vitamin D₂ Analogues

Hu Daihua ,
Chen Wang

Vitamin D Research Institute, Shaanxi Sci-Tech University, Hanzhong 723000

Received Date: 19 December 2016
Accepted Date: 8 April 2017

Figures(1)

1α, 25-Dihydroxyvitamin D₂(1α, 25-(OH)₂-D₂; 125D2) is the active metabolite form of vitamin D₂, and 1α, 25-dihydroxyvitamin D₃(1α, 25-(OH)₂-D₃; 125D) is the most active metabolite of vitamin D₃. The biological activity of 125D2 and 125D is similar, but the therapeutic application of 125D is limited by induction of hypercalcemia. Vitamin D₂ and analogues are thought to be generally less toxic than the respective vitamin D₃ compounds. This article reviews the recent development of two 125D2 analogues (doxercalciferol and paricalcitol) showed good clinical effect in organic syntheses, and new research in the design and syntheses of the structural modifications in the side chain, 19-nor, C3-substituted in A ring, and nonadeuterated isotope labeling 125D2 analogues, and the relation between the structure and the biological activities, aimed at guiding significance to the syntheses and clinical development of new selective biological vitamin D₂ analogues.
- 1α, 25-dihydroxyvitamin D₂,
- Analogues,
- Doxercalciferol,
- Paricalcitol,
- Synthesis,
- Biological activities
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Advances in Syntheses and Biological Activities of Vitamin D₂ Analogues