Citation: Li Yuhui, Yin Fangfei, Li Jiang, Li Lanying, Liu Gang. Application of Framework Nucleic Acids in Protein Precise Arrangement[J]. Chemistry, ;2020, 83(9): 770-776. shu

Application of Framework Nucleic Acids in Protein Precise Arrangement

Li Yuhui ^1,2 ,
Yin Fangfei ^1,2 ,
Li Jiang ^1,4 ,
Li Lanying ³ ,
Liu Gang ^3,,

1.
Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800
2.
University of Chinese Academy of Sciences, Beijing, 100049
3.
Laboratory of Biometrology, Shanghai Institute of Measurement and Testing Technology, Shanghai, 201203
4.
Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, 201210

Corresponding author: Liu Gang, liug@simt.com.cn
Received Date: 15 January 2020
Accepted Date: 22 April 2020

Figures(4)

In addition to being the carrier of genetic information, DNA has attracted wide interest as a new class of material in the synthetic realm. The exploitation of the precise and programmable Watson-Crick base pairing of DNA or RNA has led to the development of exquisite nucleic acid nanostructures from one to three dimensions. Advances in computer-aided tools have also facilitated the automated design of DNA nanostructures with various sizes and shapes. The "framework nucleic acids (FNAs)" constructed in recent years provide a new method for precise organization of biological macromolecules with nanometer precision. The intrinsic biological properties and tailorable functionalities of FNAs hold great promise for physical, chemical, and biological applications. This review elaborates the concept of precise self-assembled FNAs, and summarizes the recent advances of FNAs in the field of protein precise arrangement. The unique features of FNAs that benefit the arrangement of proteins and their performance are highlighted. The challenges and opportunities of this field are also discussed.
- Framework Nucleic Acids,
- DNA nanotechnology,
- DNA origami,
- Protein precise arrangement
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