Citation: Jian HU, Xiao Da YANG, Kui WANG. The Different Fluorescent Response of Quin 2 to the Binding of Ca²⁺ and La³⁺ and its Application[J]. Chinese Chemical Letters, ;2004, 15(10): 1197-1120. shu

The Different Fluorescent Response of Quin 2 to the Binding of Ca²⁺ and La³⁺ and its Application

Jian HU ^1, ,
Xiao Da YANG ^1,2 ,
Kui WANG ^1,2

1.
Department of Chemical biology, School of Pharmaceutical Sciences, Peking University, Beijing 100083;
2.
National Research Laboratories of Natural and Biomimetic Drugs, Peking University, Beijing 100083

Received Date: 22 August 2003

Fund Project: The authors thank the NNSFC for financial support of this work (No.20101001).

The fluorescence spectra of Quin 2, (2-[(2-bis-[carboxymethyl] amino-5-methylphenoxy)methyl]-6-methoxy-8-bis[carboxymethyl] aminoquiniline), a Ca²⁺ probe, were investigated upon incubation with Ca²⁺ or La³⁺. The results showed that binding of La³⁺ to Quin 2 resulted in different fluorescent spectrum from that of Ca²⁺. Based on this observation, a fluorescent method was developed for simultaneously determination of the dissociation rates of Ca²⁺ and La³⁺ from a Ca-La-calmodulin complex (Ca₂La₂CaM).
- Quin 2,
- fluorescence,
- Ca²⁺,
- La³⁺,
- calmodulin
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