Citation: Hong CHEN, Long En ZHOU, Yan Jun ZHANG, De Quan YU. Synthesis of (+) 8-O-Cinnamyl-p-chlorogoniotriol and its Analogues[J]. Chinese Chemical Letters, ;1999, 10(6): 449-452. shu

Synthesis of (+) 8-O-Cinnamyl-p-chlorogoniotriol and its Analogues

Institute of Meteria Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050

Received Date: 30 December 1998

Fund Project: The work is supported by the National Natural Science Foundation of China and the Doctoral Foundation of State Education Commission of China. We thank the Department of Instrumental Analysis of our Institute for IR. MS. ¹HNMR and [α]D²⁸ measurement.

(+)8-O-Cinnamyl-p-chlorogoniotriol (p-chlorohowiinol A) and its analogues have been synthesised in nine steps from α-D-glucoheptonic-γ-lactonc. Pharmacological tests showed that most of the compounds possessed antitumor activities toward tumor cell in voro.
- Stereoselective synthesis,
- (+)8-O-cinnamy-p-chlorgoniotriol(p-chlorohowiibnol A),
- antitumor activiyty,
- analogues
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