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Citation: Chen Wang, Hu Daihua, Feng Zili, Wang Yongji. Synthesis of 1α-Hydroxydehydroepiandrosterone[J]. Chemistry, ;2018, 81(1): 88-91. shu

Synthesis of 1α-Hydroxydehydroepiandrosterone

Vitamin D Research Institute, Shaanxi University of Technology, Hanzhong 723001

Corresponding author: Chen Wang, chenwang0519@126.com
Received Date: 5 July 2017
Accepted Date: 26 October 2017

Figures(1)

1α-hydroxydehydroepiandrosterone was prepared from androsta-1, 4-diene-3, 17-dione through seven steps such as protection of carbonyl group, bromination, deconjugation, reduction, epoxidation, ring-opening and deprotection, with an overall yield of 28.3%. The method has the advantages of high efficiency and economy, technical feasibility, safety and environmentally benign, and lays a foundation for industrialized production of 1α-hydroxydehydroepiandrosterone and research of vitamin D drugs.
- 1α-Hydroxydehydroepiandrosterone,
- Androsta-1, 4-diene-3, 17-dione,
- Epoxidation,
- Synthesis
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