Citation: Jian Xun ZHANG, Chen Chen LI, Zheng CHEN, Zhi Hua RAO, Da Wei WEN, Ke An LI, Hu Wei LIU. Metabolism Study on Tobacco-specific N-Nitrosamines in Rabbit by Solid-phase Extraction and Liquid Chromatography-electrospray Ionization-mass Spectrometry Method[J]. Chinese Chemical Letters, ;2005, 16(12): 1633-1636. shu

Metabolism Study on Tobacco-specific N-Nitrosamines in Rabbit by Solid-phase Extraction and Liquid Chromatography-electrospray Ionization-mass Spectrometry Method

College of Chemistry and Molecular Engineering, Peking University, Beijing 100871

Received Date: 4 April 2005

Metabolism of four tobacco-specific N-nitrosamines (TSNAs), N'-nitrosonornicotine(NNN), N'-nitrosoanatabine (NAT), N'-nitrosoanabasine (NAB) and 4-(methyl nitrosamino)-l-(3-pyridyl)-l-butanone (NNK) was studied by solid-phase extraction (SPE) and liquid chromato-graphy-electrospray ionization-mass spectrometry (LC-ESI-MS). SPE and LC-ESI-MS method was evaluated to be rapid, simple, sensitive and selective for analysis of TSNAs in rabbit serum.The doses of TSNAs administrated were 4.666 μg/kg and 11.665 μg/kg according to different levels in cigarettes. Metabolic curves of four TSNAs and 4-(methyl nitrosamino)-1-(3-pyridyl)-1-butanone (NNAL), the metabolite of NNK, were obtained.
- Tobacco-specific N-nitrosamines,
- metabolism,
- liquid chromatography-electrospray interface-mass spectrometry
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