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Citation: Liu Lei, Wang Lili, Lv Haijun, Kang Caihong. Study on the Synthesis and Its Process of Ranitidine[J]. Chemistry, ;2017, 80(2): 212-215. shu

Study on the Synthesis and Its Process of Ranitidine

Liu Lei ^1,2 ,
Wang Lili ¹ ,
Lv Haijun ^1,#,, ,
Kang Caihong ¹

1.
Hebei Research Center of Pharmaceutical and Chemical Engineering, College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018
2.
Hebei Key Laboratory of Molecular Chemistry for Drug, Hebei Research Center of Pharmaceutical and Chemical Engineering, Shijiazhuang 050018

Corresponding author: Lv Haijun, haijun_lv@126.com
Received Date: 11 August 2016
Accepted Date: 20 September 2016

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In this paper, the traditional chemical synthesis methods have been modified to get ranitidine with high yield and purity. Under the protection of nitrogen, N-methyl-1-alkylthio-2-nitroethenamines (referred to as "three side") and 2-[[[5-(dimethylamine)methyl-furan-2-yl]methyl]thio]ethylamine(referred to as "thiobisethylamine") as starting materials in the mole ratio of 1.156:1 was added to the water, keep the temperature at 36℃ for 4h. The reaction mixture was acidified to pH 3.5~4 and extracted with dichloromethane. The organic phase can be used to recycle three side with high recovery rate of 98.9%. Aqueous phase was basified to pH 9~10, then extracted with dichloromethane again, dried, filtered, evaporated, and recrystallized to get ranitidine with yield of 89.7%.
- Thiobisethylamine,
- Ranitidine
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