Citation: Cong Fa LI, Qiao LIU, Hong Jie CUI, Di DING, Ai Guo JI, Yin Bo QU. Epoxide Hydrolase-catalyzed Resolution of Ethyl 3-Phenylglycidate[J]. Chinese Chemical Letters, ;2003, 14(11): 1133-1134. shu

Epoxide Hydrolase-catalyzed Resolution of Ethyl 3-Phenylglycidate

Cong Fa LI ^1,2, ,
Qiao LIU ¹ ,
Hong Jie CUI ³ ,
Di DING ¹ ,
Ai Guo JI ³ ,
Yin Bo QU ¹

1.
State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100;
2.
College of Engineering, South China University of Tropical Agriculture, Hainan 571737;
3.
College of Pharmacy, Shandong University, Jinan 250012

Received Date: 2 January 2002

Fund Project: This work was financially supported by the Natural Science Foundation of Shandong Province (No. Y2000C21) and the National Natural Science Foundation of China (No. 30270047).

Epoxide hydrolase-catalyzed resolution of ethyl 3-phenylglydidate was investigated using resting cells of Pseudomonas sp. BZS21. Under the present conditions 26.2% of (2R, 3S)-ethyl 3-phenylglycidate with ee value of 94.6% was obtained from the racemic mixture.
- Epoxide hydrolase,
- ethyl 3-phenylglycidate,
- resolution,
- asymmetric hydrolysis
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