Citation: Wang Yanni, Feng Ailing, Xu Rong. Nano Metal Organic Frameworks and Their Application of Drug Delivery[J]. Chemistry, ;2019, 82(4): 291-298. shu

Nano Metal Organic Frameworks and Their Application of Drug Delivery

School of Physics and Optoelectronics Technology, Baoji University of Arts & Sciences, Baoji 721016

Corresponding author: Feng Ailing, ailing@mail.xjtu.edu.cn
Received Date: 29 November 2018
Accepted Date: 25 December 2018

Figures(4)

Metal organic frameworks (MOFs) are coordination polymers formed by metal ions and polydentate organic ligands containing nitrogen and oxygen by self-assembly process, which have been widely applied in drug delivery systems due to their advantages such as large specific surface area and high porosity. Nano metal organic frameworks (NMOFs) materials have not only the properties of MOFs, but also the unique physical and chemical properties of nanomaterials. Taken into account their characteristics of high drug loading capacity, good targeting ability, versatile functionality and good biodegradability, NMOFs have become excellent nano-scale drug delivery systems. This article mainly featured recent research progress towards various preparation methods of NMOFs, including solvothermal method, reverse microemulsion method, and ultrasonic method. And the advantages and disadvantages of these methods were discussed respectively. Meanwhile, the characteristics of NMOFs used drug delivery systems and the load of different types of drugs are described in detail. Finally, the future of their main research direction is prospected, which include improving its biocompatibility, more effective surface functionalization, expanding the variety of biological NMOFs and their payload drugs. So that, NMOFs can be used in the treatment of more diseases.
- Nano metal organic frameworks,
- Coordination compounds,
- Specific surface area,
- Porosity,
- Drug delivery
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