Citation: Ji Cheng CHU, Dong Zhi LIU, Hong Sheng GUO, Kang ZHAO. Approach to N-Alkoxy-2-oxoindole for Mimicing SERMs Structure[J]. Chinese Chemical Letters, ;2005, 16(12): 1593-1596. shu

Approach to N-Alkoxy-2-oxoindole for Mimicing SERMs Structure

1.
School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072;
2.
Medical College, Chinese People's Armed Police Force, Tianjin 300071;
3.
College of Pharmaceutical and Biotechnology, Tianjin University, Tianjin 300072

Received Date: 1 April 2005

Treatment of N-alkoxyamides with bis(trifluoroacetoxy)iodobenzene generated electron deficient nitrogen species, which readily cyclized onto aromatic ring to give N-alkoxy-2-oxoindoles. The effect of different substituent on aromatic ring to the electrophilic substitution was studied.
- N-Alkoxyamides,
- bis(trifluoroacetoxy)iodobenzene,
- intramolecular cyclization
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