Citation: Zhao Peipei, Zheng Wenhui, Bu Min, He Wanlin, Cai Yan. Progress in Development of Coronavirus Inhibitors[J]. Chemistry, ;2020, 83(8): 674-689. shu

Progress in Development of Coronavirus Inhibitors

Zhao Peipei ¹ ,
Zheng Wenhui ² ,
Bu Min ² ,
He Wanlin ^1,, ,
Cai Yan ^1,,

1.
Tianjin International Joint Academy of Biomedicine, Tianjin, 300457
2.
College of Pharmacy, Nankai University, Tianjin, 300071

Corresponding author: He Wanlin, hwl1558714@163.com Cai Yan, caiyan_86@163.com
Received Date: 5 June 2020
Accepted Date: 14 June 2020

Figures(26)

Coronaviruses are a kind of widely exist pathogens that could cause serious health hazard to human and multiple species of animals, among them, Severe Acute Respiratory Syndrome virus (SARS-CoV)and Middle East respiratory syndrome (MERS-CoV)were broken out in 2003 and 2012 respectively, both of them cause serious health risk to human and considerable loss to global economy. Especially, the Novel Coronavirus(SARS-CoV-2)which was broken out at the end of 2019 has caused millions of infections and tens of thousands death. It is obviously that coronaviruses are highly contagious infectious virus with high mortality rate, which seriously threaten people's health and safety. However, there is no effective drug approved for treatment of them and no vaccine for protect people at present. In this review, we introduced the drugs-like target in coronaviruses and the design and synthesis of representative inhibitors of them, hoping to provide some references for the development of effective therapeutic drugs.
- Coronaviruses,
- Inhibitor,
- Drug-like target,
- Drug synthesis
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