Citation: Zhang Chong, Hou Yingqin, Lv Hua. The Secondary Structure Effect of Poly(α-Amino Acid)s in Materials Sciences and Biomedical Applications[J]. Chemistry, ;2020, 83(4): 343-348. shu

The Secondary Structure Effect of Poly(α-Amino Acid)s in Materials Sciences and Biomedical Applications

Beijing National Laboratory for Molecular Sciences, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, Center for Soft Matter Science and Engineering, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871

Corresponding author: Lv Hua, chemhualu@pku.edu.cn
Received Date: 17 December 2019
Accepted Date: 8 January 2020

Figures(3)

Poly(α-amino acid)s (PαAAs), or synthetic polypeptides, are biodegradable and biocompatible polymers with unique secondary structures (e.g. α-helix, β-sheet, and random coil) resembling natural proteins. The secondary structures and their stimuli-responsive transitions endow PαAAs a wide range of applications for both material sciences and biomedicine. In this review, we give a brief summary of our recent progresses in the secondary structure effect of PαAAs with special focuses placed on antifouling surfaces, regulation of cellular uptake, and protein modification, the future development direction of the secondary structure of PαAAs was briefly predicted.
- Poly(α-amino acid),
- Secondary structure,
- Antifouling polymer,
- Cellular uptake,
- Protein-polymer conjugates
1. [1]
  Lu H, Wang J, Song Z, et al. Chem. Commun., 2014, 50(2):139~155.
2. [2]
  Deming T J. Chem. Rev., 2016, 116(3):786~808.
3. [3]
  Shen Y, Fu X, Fu W, et al. Chem. Soc. Rev., 2015, 44(3):612~622.
4. [4]
  Deng C, Wu J, Cheng R, et al. Prog. Polym. Sci., 2014, 39(2):330~364.
5. [5]
  Huang J, Heise A. Chem. Soc. Rev., 2013, 42(17):7373~7390.
6. [6]
  Hadjichristidis N, Iatrou H, Pitsikalis M, et al. Chem. Rev., 2009, 109(11):5528~5578.
7. [7]
  Song Z, Tan Z, Cheng J. Macromolecules, 2019, 52(22):8521~8539.
8. [8]
  Yuan J, Sun Y, Wang J, et al. Biomacromolecules, 2016, 17(3):891~896.
9. [9]
  Wu Y, Zhang D, Ma P, et al. Nat. Commun., 2018, 9:5297.
10. [10]
  Niwa M, Morikawa M, Higashi N. Angew. Chem. Int. Ed., 2000, 39(5):960~963.
11. [11]
  Rodríguez-HernándezJ, Lecommandoux S. J. Am. Chem. Soc., 2005, 127(7):2026~2027.
12. [12]
  Kramer J R, Deming T J. J. Am. Chem. Soc., 2012, 134(9):4112~4115.
13. [13]
  Cheng Y, He C, Xiao C, et al. Biomacromolecules, 2012, 13(7):2053~2059.
14. [14]
  Chen C, Wang Z, Li Z. Biomacromolecules, 2011, 12(8):2859~2863.
15. [15]
  Wang S, He W, Xiao C, et al. Biomacromolecules, 2019, 20(4):1655~1666.
16. [16]
  Baumgartner R, Fu H, Song Z, et al. Nat. Chem., 2017, 9:614~622.
17. [17]
  Chen C, Lan J, Li Y, et al. Chem. Mater., 2019, 10.1021/acs. chemmater. 9b04160.
18. [18]
  Yin L, Tang H, Kim K H, et al. Angew. Chem. Int. Ed., 2013, 52(35):9182~9186.
19. [19]
  Tang H, Yin L, Kim K H, et al. Chem. Sci., 2013, 4(10):3839~3844.
20. [20]
  Xiong M, Han Z, Song Z, et al. Angew. Chem. Int. Ed., 2017, 56(36):10826~10829.
21. [21]
  Mochida Y, Cabral H, Miura Y, et al. ACS Nano, 2014, 8(7):6724~6738.
22. [22]
  Ma Y, Shen Y, Li Z. Mater. Chem. Front., 2017, 1(5):846~851.
23. [23]
  Bonduelle C. Polym. Chem., 2018, 9(13):1517~1529.
24. [24]
  Song Z, Fu H, Wang R, et al. Chem. Soc. Rev., 2018, 47(19):7401~7425.
25. [25]
  Cai C, Lin J, Lu Y, et al. Chem. Soc. Rev., 2016, 45(21):5985~6012.
26. [26]
  Song Z, Han Z, Lv S, et al. Chem. Soc. Rev., 2017, 46(21):6570~6599.
27. [27]
  Banerjee I, Pangule R C, Kane R S. Adv. Mater., 2011, 23(6):690~718.
28. [28]
  Blaszykowski C, Sheikh S, Thompson M. Chem. Soc. Rev., 2012, 41(17):5599~5612.
29. [29]
  Knop K, Hoogenboom R, Fischer D, et al. Angew. Chem. Int. Ed., 2010, 49(36):6288~6308.
30. [30]
  Gillich T, Benetti E M, Rakhmatullina E, et al. J. Am. Chem. Soc., 2011, 133(28):10940~10950.
31. [31]
  Li L, Yan B, Zhang L, et al. Chem. Commun., 2015, 51(87):15780~15783.
32. [32]
  Morgese G, Trachsel L, Romio M, et al. Angew. Chem. Int. Ed., 2016, 55(50):15583~15588.
33. [33]
  Zhang C, Yuan J, Lu J, et al. Biomaterials, 2018, 178:728~737.
34. [34]
  Saha K, Agasti S S, Kim C, et al. Chem. Rev., 2012, 112(5):2739~2779.
35. [35]
  Kim D, Kim J, Park Y I, et al. ACS Cent. Sci., 2018, 4(3):324~336.
36. [36]
  Banik B L, Fattahi P, Brown J L. Polymeric Nanoparticles:The Future of Nanomedicine WIREs Nanomed. Nanobiotechnol., 2016, 8:271~299.
37. [37]
38. [38]
  Ding Y, Du C, Qian J, et al. Nano. Lett., 2019, 19(7):4362~4370.
39. [39]
40. [40]
  Behzadi S, Serpooshan V, Tao W, et al. Chem. Soc. Rev., 2017, 46(14):4218~4244.
41. [41]
  Zhao F, Zhao Y, Liu Y, et al. Small, 2011, 7(10):1322~1337.
42. [42]
  Jiang W, Kim B Y S, Rutka J T, et al. Nat. Nanotechnol., 2008, 3:145~150.
43. [43]
  Li Y, Kröger M, Liu W K. Nanoscale, 2015, 7(40):16631~16646.
44. [44]
  Hühn D, Kantner K, Geidel C, et al. ACS Nano, 2013, 7(4):3253~3263.
45. [45]
  Sun J, Zhang L, Wang J, et al. Adv. Mater., 2015, 27(8):1402~1407.
46. [46]
  Li Y, Chen X, Gu N. J. Phys. Chem. B, 2008, 112(51):16647~16653.
47. [47]
  Lindgren M, Hällbrink M, Prochiantz A, et al. Trends Pharmacol. Sci., 2000, 21(3):99~103.
48. [48]
  Zhang C, Lu J, Tian F, et al. Nano Res., 2019, 12(4):889~896.
49. [49]
  Hou Y, Lu H. Bioconj. Chem., 2019, 30(6):1604~1616.
50. [50]
  Abu LilaA S, Kiwada H, Ishida T. J. Control. Release, 2013, 172(1):38~47.
51. [51]
  Zhang P, Sun F, Liu S, et al. J. Control. Release, 2016, 244(28):184~193.
52. [52]
53. [53]
  Hou Y, Zhou Y, Wang H, et al. J. Am. Chem. Soc., 2018, 140(3):1170~1178.
54. [54]
  Hou Y, Yuan J, Zhou Y, et al. J. Am. Chem. Soc., 2016, 138(34):10995~11000.
55. [55]
  Hou Y, Zhou Y, Wang H, et al. ACS Cent. Sci., 2019, 5(2):229~236.
56. [56]
  Wu G, Ge C, Liu X, et al. Chem. Commun., 2019, 55(54):7860~7863.
57. [57]
  Yuan J, Zhang Y, Sun Y, et al. Biomacromolecules, 2018, 19(6):2089~2097.
58. [58]
  Xiong W, Fu X, Wan Y, et al. Polym. Chem., 2016, 7(41):6375~6382.
59. [59]
  Gharakhanian E G, Bahrun E, Deming T J. J. Am. Chem. Soc. 2019, 141(37):14530~14533.
60. [60]
  Liu H, Wang R, Wei J, et al. J. Am. Chem. Soc. 2018, 140(21):6604~6610
61. [61]
  Grazon C, Salas-Ambrosio P, Ibarboure E, et al. Angew. Chem. Int. Ed., 2020, 59(2):622~626.
62. [62]
  Zhao W, Lv Y, Li J, et al. Nat. Commun., 2019, 10:3590.
63. [63]
  Zhao L, Wang X, Sun L, et al. Polym. Chem., 2019, 10(38):5206~5214.
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

The Secondary Structure Effect of Poly(α-Amino Acid)s in Materials Sciences and Biomedical Applications

南开大学师唯/华北电力大学（保定）刘景维：二维配位聚合物中有序的亲锂冠醚位点用于无枝晶锂沉积

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通讯作者: 陈斌, bchen63@163.com